Serum Beta 2 Microglobulin Levels In Ankylosing Spondylitis And Disease Activity: [Ankilozan Spondilitis'li Olgularda Serum Beta 2 Mikroglobulin Düzeyleri Ve Hastalık Aktivitesi İle İlişkisi]

Yalçın KEPEKÇİ; Can BOĞA; Fikri BAŞLAMIŞLI; Eren ERKEN; Mustafa DEMİRTAŞ

doi:10.58600/eurjther.19920302-1050

Authors

Yalçın KEPEKÇİ Gaziantep Üniversitesi Tıp Fakültesi İç Hast. ABD. Yrd.Doç.Dr .
Can BOĞA Gaziantep Üniversitesi Tıp Fakültesi İç Hast. ABD. Doç.Dr .
Fikri BAŞLAMIŞLI Çukurova Üniversitesi Tıp Fakliltesi İç Hast. ABD. Yrd.Doç.Dr.
Eren ERKEN Çukurova Üniversitesi Tıp Fakültesi İmmünoloji Bilim Dalı. Prof.Dr.
Mustafa DEMİRTAŞ Çukurova Üniversitesi Tıp Fakültesi Kardiyoloji Bilim Dalı. Doç.Dr.

DOI:

https://doi.org/10.58600/eurjther.19920302-1050

Keywords:

Ankyilosing spımdylitis, Beta 2 Microglobulin, Fibrinogen, Copper, HLA

Abstract

Serum Beta 2 microglobulin levels in ankylosing spondylitis and disease activity Serum levels of beta 2 microglobulin were investigated in patients with ankylosing spondylitis by the use of microparticle enzyme immunoassay (MEIA) method. Patients were devided to two groups acording to their clinical activities. Serum beta 2 microglobulin levels in ankylosing spondilitis were not statistically different from the values of controls (p>0.05) and correlated with no variable investigated (serum fibriogen, ESR, Serum copper, CRP). Beta 2 microglobulin levels were not significating decreased in the B27 positive group with AS compared with the B27 negative group. In summary, serum beta 2 microglobulin levels seem not to be a good marker in the diagnosis of disease arid its activity of AS.

Metrics

Metrics Loading ...

References

Evrin PE, Wibell L. The serum levels and urinaryexcretion of B2 microglobulin in apparently health subjects. Scand J Oin lab invest 29:69, 1972

Konenkov VI., Prokofev VF., Glazysheva Ilu., et al Changes in the levels of soluble HLA antigens and their light chains (beta 2 micro globulin) in rheumatoid arthritis and systemic lupus erythematasus Ter Arkh 58 (7):57-9, 1986

Curry R., Then J., Shelbome C., et al. Antibodies to elevations of beta 2 microglobulin in the serum of ankybsing spondilities patients Arth.Rheumaaatol 25(4),375-380, 1982

Rodriquea M., Lira P., Foredori A., et al Beta 2 microglobulin in some hematologic neoplasms. Rev Med Chil 116(6), 538-42, 1989

Meryhow NL, Zoschke DC., Messner RP. Anti beta 2 microglobulin antibodies in systemic lupus esythematosus and ankylosing spondilities: effects on in vitro lymphocyte function, J Rhematol 13:83-9,1986

0auss A: Gerinnung physiologische schnelimethods Zur Bestimmung des Fibrinogens. ACta Haematol: 17,287-41, 1957

Terasaki Pi: Microdroplet Lymphosyte cytotoxicity test in: Ray JG, Hare DB, Pederson PO and Mollaly Dl (Edg) Manual of Tissue Typing Techniques DHEN Publication Bathesda, 1975 No(NH) 76-545, pp.69-80.

Fan PT., Oements PJ., Yu DTY., et al Lynphocytes abnormalities in ackylosing spondylitis Ann Rhemm Dis 36:471-473, 1977

Vincent C., Robert M., Revillard JP. Effect of anti B 2 microglonulin antibodies on human lymphocytes.Cell Immunol 18, 152-166,1975

0stberg L., Lindblom JB, Peterson PA, B2 microglobulin on the cell surface specificity of inhibition of the mixed leukocyte reaction and mitogenic prroperties of antibodies against the two HLA polypeptide chains . Eur Immunol 6:108-113, 1976

Norfolk DR., Forbes MA., Cooper EH., et al Changer in plasma beta 2 micriglobulin concentrations after allogenic lone morow transplantation. J Oin Pathol 40(6), 657-62, 1987

Weissel M, Scherak V., Fritzscke H., et al Serum Beta 2 microglobulin and SLE Arthuritis Rheum 19,968,1976

Todesco S., Punzil I., Montanaro D., et al Beta 2 mivcroglobulin in synovial fluid in rheumatoid arthritis. J Rheumatol 7:553-8, 1980

Wendling O., Guidet M. Serum beta 2 microglobulin in ankylosing spondilitis (letter) J.Rheumatol 16(10), 1399, 1989

Sorensan R.J.R.: Anti-inflammatory, anti-ulcer and analgesic activities of copper complexes offera pharmacological approach to treatment of rheumatoid arthritis. Current trends in trace elements research. Chazot G, Abdullah M, Arnond P (Eds) 1989. Smith Gordon and Company Limited, pp.154-61.

Hallgren R., Feltelius N., Lindh U: Redistribution of minerals and trace elements in chronic inflammation - a study on isolated blood cells from patients with ankylosing spondylitis. J Rheumatol: 14(3): 548-53. 1987