Epileptic seizure associated with drugs: Report of two cases: İlaç ilişkili epileptik nöbet: İki olgu sunumu

Çetin Kürşad Akpınar; Hakan Doğru; Nilgün Cengiz

doi:10.5455/GMJ-30-174128

Authors

Çetin Kürşad Akpınar Department of Neurology, Vezırkopru State Hospital, Samsun, Turkey
Hakan Doğru Department of Neurology, Faculty of Medicine, University of Ondokuz Mayıs, Samsun, Turkey
Nilgün Cengiz Department of Neurology, Faculty of Medicine, University of Ondokuz Mayıs, Samsun, Turkey

DOI:

https://doi.org/10.5455/GMJ-30-174128

Keywords:

Doxorubicin, epileptic seizure, maprotiline

Abstract

A febrile seizure rate is 2-5%, throughout the life of a human in a population. Drug-induced seizures are relatively rare. Numerous drugs have been suspected to be associated with the occurrence of epileptic seizures. The risk of seizure is greatest in patients predisposed to seizure by use of conventional antipsychotics, olanzapine, risperidone, bupropion, tricyclic antidepressants, cyclosporin, interferon, corticosteroids, propofol, imipenem, and chloroquine. In this paper, two cases with suspicion of drug induced seizures were presented.

Metrics

Metrics Loading ...

References

Garcia PA, Allredge BK. Drug-induced seizures. Neurol Clin 1994; 12(1): 85-9.

Baumann PA, Maitre L. Neurobiochemical aspects of maptotiline (Ludiomil) action. J Int Med Res 1979; 7(5): 391-00.

Reuther LO, Pedersen ST, Ronn AM. Drug-induced seizures. Ugeskr Laeger 2003; 165: 1447-51 (Article in Danish) (Abstract).

Noyes RJr, Garvey MJ, Cook BL, Samuelson L. Problems with tricyclic antidepressant use in patient with panic disorder or agoraphobia: result of a naturalistic followup study. J Clin Psychiatry 1989; 50(5): 163-9.

Bridgers SL. Epileptiform abnormalities discovered on electroencephalographic screening of psychiatric inpatients. Arch Neurol 1987; 44: 312-6.

Moore NC, Tucker KA, Brin FB, Merai P, Schillcut, SD, Coburn KL. Positive symptoms of schizophrenia:response to haloperidol and remoxipiride is associated with increased alpha EEG activity. Hum Psychopharmacol 1997; 12: 75-80.

Centorrino F, Price BH, Tuttle M, Bahk WM, Hennen J, Albert MJ, et al. EEG abnormalities during treatment with typical and atypical antipsychotics. Am J Psychiatry 2002; 159: 109-15.

Pisani F, Oteri G, Costa C, Di Raimondo G, Di Perri R. Effects of Psychotropic Drugs on Seizure Threshold. Drug Safety 2002; 25(2): 91-110.

Momparler RL, Karon M, Siegel SE, Avila F. Effect of Adriamycin on DNA, RNA and Protein Synthesis in Cell-Free Systems and Intact Cells. Cancer Res 1976; 36: 2891–95.