The role of platelet indices in determining atopy in childhood asthma: Çocukluk çağı astımında atopinin belirlenmesinde trombosit indekslerinin rolü

Buket Kın Tekçe; Mustafa Erkoçoğlu; Mustafa Dilek; Ali Fuat Serpen

doi:10.5455/GMJ-30-79793

Authors

Buket Kın Tekçe Department of Medical Biochemistry, Faculty of Medicine, University of Abant İzzet Baysal, Bolu
Mustafa Erkoçoğlu Department of Pediatric Allergy and Immunology, Faculty of Medicine, University of Abant İzzet Baysal
Mustafa Dilek Department of Newborn, Faculty of Medicine, University of Abant İzzet Baysal, Bolu
Ali Fuat Serpen Department of Pediatrics, Faculty of Medicine, University of Abant İzzet Baysal, Bolu

DOI:

https://doi.org/10.5455/GMJ-30-79793

Keywords:

Platelet indices, asthma, atopy

Abstract

Asthma is the most common chronic airways disease of childhood. Allergic asthma is the most common phenotype in childhood. Definition of allergic asthma is typically based on presence or absence of atopy. In asthma, platelets have been found to actively participate in airway inflammation. The aim of this study is to evaluate levels of platelet indices in atopic and non-atopic asthmatic patients and to investigate the usefulness as a marker for the detection of atopy. Patients with asthma between January 2014 and January 2015 were retrospectively screened. 142 patients who fit for inclusion exclusion criteria enrolled into the study. Patients were grouped according to the skin prick test. The results of a complete blood count, serum total Ig E results were obtained from the laboratory information system. The percentage of eosinophils, total Ig E levels, platelet distribution width; was significantly higher in the group with atopic asthma (respectively p=<0.001, <0.001, 0.018). On the other hand platecrit atopic asthmatic group (n=72) was significantly lower than non-atopic (n=70). (p=0.016). The ROC curves analysis were constructed in order to test the ability of platelet distribution width and PCT levels to predict atopy. The area under ROC curve of PDW was 0.60 [95% confidence interval (CI) 0.52-0.68; p=0.031] and cut-off value was >15.9. The area under ROC curve of PCT was 0.58 [95% confidence interval (CI) 0.49-0.66; p=0.095] and cut-off value was <0.32. The results of this study shows that platelet distribution width may determine the phenotype of asthma. So, prospective, multicenter studies with larger cohort may obtain further data about platelet distribution width in asthma.

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References

Bacharier LB, Boner A, Carlsen KH, Eigenmann PA, Frischer T, Gotz M, et al. Diagnosis and treatment of asthma in childhood: a PRACTALL consensus report. Allergy 2008;63(1):5-34.

Kornerup KN, Page CP. The role of platelets in the pathophysiology of asthma. Platelets 2007;18(5):319-28.

Moore WC, Meyers DA, Wenzel SE, Teague WG, Li HS, Li XN, et al. Identification of asthma phenotypes using cluster analysis in the severe asthma research Program. Am J Resp Crit Care 2010;181(4):315-23.

Pekkanen J, Lampi J, Genuneit J, Hartikainen AL, Jarvelin MR. Analyzing atopic and non-atopic asthma. Eur J Epidemiol 2012;27(4):281-6.

Ulfman LH, Joosten DPH, van Aalst CW, Lammers JWJ, van de Graaf E, Koenderman L, et al. Platelets promote eosinophil adhesion of patients with asthma to endothelium under flow conditions. Am J Resp Cell Mol 2003;28(4):512-9.

Pitchford SC, Riffo-Vasquez Y, Sousa A, Momi S, Gresele P, Spina D, et al. Platelets are necessary for airway wall remodeling in a murine model of chronic allergic inflammation. Blood 2004;103(2):639-47.

Leader A, Pereg D, Lishner M. Are platelet volume indices of clinical use? A multidisciplinary review. Ann Med 2012;44(8):805-16.

Farias MG, Schunck EG, Dal Bo S, de Castro SM. Definition of reference ranges for the platelet distribution width (PDW): a local need. Clin Chem Lab Med 2010;48(2):255-7.

Steiropoulos P, Papanas N, Nena E, Xanthoudaki M, Goula T, Froudarakis M, et al. Mean platelet volume and platelet distribution width in patients with chronic obstructive pulmonary disease: the role of comorbidities. Angiology 2013;64(7):535-9.

Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention 2014. Available from; www.ginasthma.org.

Van der Lelie J, Von dem Borne AK. Platelet volume analysis for differential diagnosis of thrombocytosis. J Clin Pathol 1986;39(2):129-33.

Nelson HS, Knoetzer J, Bucher B. Effect of distance between sites and region of the body on results of skin prick tests. J Allergy Clin Immun 1996;97(2):596-601.

Yuksel O, Helvaci K, Basar O, Koklu S, Caner S, Helvaci N, et al. An overlooked indicator of disease activity in ulcerative colitis: Mean platelet volume. Platelets 2009;20(4):277-81.

Makay B, Turkyilmaz Z, Duman M, Unsal E. Mean platelet volume in Henoch-Schonlein purpura: relationship to gastrointestinal bleeding. Clin Rheumatol 2009;28(10):1225-8.

Kisacik B, Tufan A, Kalyoncu U, Karadag O, Akdogan A, Ozturk MA, et al. Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine 2008;75(3):291-4.

Pitchford SC, Page CP. Platelet activation in asthma: integral to the inflammatory response. Clin Exp Allergy 2006;36(4):399-401.

Ahlstedt S, Murray CS. In vitro diagnosis of allergy: how to interpret IgE antibody results in clinical practice. Prim Care Respir J 2006;15(4):228-36.