Cardiac functions in children with iron deficiency anemia: Demir eksikliği anemili çocuklarda kardiyak fonksiyonlar

Doğan Köse; Derya Arslan; Fatma Kaya; Bülent  Oran; Yavuz Köksal

doi:10.5455/GMJ-30-161895

Authors

Doğan Köse Selcuk University, Faculty of Medicine, Department of Pediatric Hematology and Oncology, Konya, Turkey
Derya Arslan Selcuk University, Faculty of Medicine, Department of Pediatric Cardiology, Konya, Turkey
Fatma Kaya Selcuk University, Faculty of Medicine, Department of Pediatrics, Konya, Turkey
Bülent Oran Selcuk University, Faculty of Medicine, Department of Pediatric Cardiology, Konya, Turkey
Yavuz Köksal Selcuk University, Faculty of Medicine, Department of Pediatric Hematology and Oncology, Konya, Turkey

DOI:

https://doi.org/10.5455/GMJ-30-161895

Keywords:

Anemia, cardiac, children, iron

Abstract

In this study, we aimed to assess the effects of iron deficiency (ID) on cardiac functions with M-mode, pulse Doppler, and tissue Doppler and to compare the findings with healthy individuals. Twenty one children with only ID (prelatent ID + latent ID + manifest ID/anemia) and completely healthy 23 children were included in the study. Of all patients, complete blood counts were studied, and serum iron (Fe), iron binding capacity (FeBC), and ferritin levels were measured. Echocardiographic assessment was performed for those who were diagnosed with Fe deficiency at the beginning of the study and after there covery of anemia and once at the beginning of the study for those who were healthy. There were significant differences between control group values and pre-treatment values of patients with manifest ID in terms of hemoglobin (Hgb), hematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red blood cell distribution width (RDW), ferritin, Fe, FeBC, aortic diameter (AD), and left atrial diameter (LAD). Between the pre- and post-treatment values of manifest ID (anemia) patients, there were significant differences in terms Hgb, Hct, MCV, MCH, MCHC, ferritin, Fe, FeBC, AD, LAD, left ventricular end systolic diameter, left ventricular end diastolic diameter, septal thickness, posterior wall thickness, ejection fraction, fractional short time, mitral, tricuspid, and septal isovolumetric relaxation time and septal isovolumetric contraction time. Diastolic and systolic cardiac dysfunction occurs at the stage of manifest ID where the value of Hgb decreased and these changes recover with treatment.

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