Creutzfeldt-Jakob disease presented with dizziness,  weakness and neuropsychiatric symptoms: 2 Case  Reports: Baş dönmesi, halsizlik ve nöropsikiyatrik semptomlar ile prezente olan  Creutzfeldt-Jakob hastalığı: 2 olgu sunumu

Yusuf  İnanç; Zülfikar  Arlıer; Yılmaz  İnanç; Sırma  Geyik; Semih Giray; Özcan   Kocatürk

doi:10.5455/GMJ-30-173253

Authors

Yusuf İnanç Başkent University School of Medicine, Department of Neurology
Zülfikar Arlıer Başkent University School of Medicine, Department of Neurology
Yılmaz İnanç Hayat Hospital, Neurology Clinics
Sırma Geyik Gaziantep University School of Medicine, Department of Neurology
Semih Giray Başkent University School of Medicine, Department of Neurology
Özcan Kocatürk Harran University School of Medicine, Department of Neurology

DOI:

https://doi.org/10.5455/GMJ-30-173253

Keywords:

Creutzfeldt-Jakob disease, dementia, myoclonus

Abstract

Creutzfeldt-Jakob disease (CJD) is among very rare, progressive, untreatable, neurodegenerative prion diseases. While the incidence is reported as 1/1000000 years in European countries, sporadic cases are rarely presented in Turkey. Clinical findings are in the form of rapid progressive dementia, myoclonus, cerebellar, pyramidal and extra pyramidal symptoms. Definitive diagnosis is established by histopathological examination. Our case is a 64-year-old male and 70-year-old female patients admitted with dizziness emerged as sub-acute weakness, nausea, vomiting, insomnia, imbalance and additional neuropsychiatric complaints. Focal activity slowness and common periodic sharp wave activities were observed in EEG. CJD was considered because bilateral symmetrical diffusion limitation was observed at both sides in the basal ganglia level in cranial diffusion MRI’s and 14-3-3 protein was resulted as positive in CSF examinations. CJD, which is a very rare disease in patients presenting with progressive neuropsychiatric symptoms and seizure, is one of the diagnosis to be considered and we wanted to emphasize that there is no treatment for it and preventive measures should be taken

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