Importance of mean platelet volume in patients with chronic obstructive pulmonary disease: Kronik obstrüktif akciğer hastalığı olan bireylerde ortalama trombosit hacminin önemi

İbrahim  Koç; Zeynel Abidin Karataş; Eray Mandollu; Aydın Mermer; Abdulaziz Kaya; Ayşen Dökme; Adem Bayraktar; Yusuf Doğan

doi:10.5455/GMJ-30-154104

Authors

İbrahim Koç Viranşehir State Hospital, Pulmonary Medicine Clinic, Şanlıurfa, Turkey
Zeynel Abidin Karataş Viranşehir State Hospital, Otolaryngology Clinic, Şanlıurfa, Turkey
Eray Mandollu Viranşehir State Hospital, Anesthesiology Clinic, Şanlıurfa, Turkey
Aydın Mermer Viranşehir State Hospital, Anesthesiology Clinic, Şanlıurfa, Turkey
Abdulaziz Kaya Viranşehir State Hospital, Anesthesiology Clinic, Şanlıurfa, Turkey
Ayşen Dökme Viranşehir State Hospital, Pulmonary Medicine Clinic, Şanlıurfa, Turkey
Adem Bayraktar Viranşehir State Hospital, General Surgery Clinic, Şanlıurfa, Turkey
Yusuf Doğan Viranşehir State Hospital, Microbiology Clinic, Şanlıurfa, Turkey

DOI:

https://doi.org/10.5455/GMJ-30-154104

Keywords:

Chronic obstructive pulmonary disease, complete blood count, mean platelet volume

Abstract

Chronic obstructive pulmonary disease (COPD) is an important public health problem and it is associated with systemic inflammation. Mean platelet volume (MPV) is one of the markers indicating platelet activation, and there are different results in different diseases related to inflammation. As for COPD some studies found it to be high whereas others found low results. In this study, we aimed to study parameters like MPV, platelet distribution volume (PDW), red blood cell (RBC), which are studied in the complete blood count testing routinely of patients with COPD, smoking and nonsmoking subjects without chronic diseases. Data of 121 patients with COPD, 101 nonsmoking subjects and 102 smoking subjects were retrospectively enrolled. Results were statistically analyzed. MPV levels were lower in patients with COPD compared with smokers (P<0.001) and nonsmoking subjects (P<0.001) but platelet levels were not significantly different. PDW levels found to be lower in COPD group compared with smokers (P<0.013) and nonsmokers (P<0.001). White blood cells were higher in patients with COPD as were expected (P<0.001). Neutrophil levels also were higher in patients with COPD compared with smokers (P<0.003) and nonsmokers (P<0.0001). RBC levels were lower in patients with COPD when compared with nonsmokers (P<0.001). The results of this study suggest that the decreased MPV and PDW may be used as negative reactants for evaluation of COPD.

Metrics

Metrics Loading ...

References

Alessandri C, Basili S, Violi F, Ferroni P, Gazzaniga P, Cordova C. Hypercoagulability state in patients with chronic obstructive pulmonary disease. Chronic Obstructive Bronchitis and Haemostasis Group. Thromb Haemost 1994;72(3):343-6.

Stein PD, Beemath A, Meyers FA, Olson RE. Pulmonary embolism and deep venous thrombosis in hospitalized adults with chronic obstructive pulmonary disease. J Cardiovasc Med (Hagerstown) 2007;8(4):253-7.

Nakstad B, Lyberg T, Skjonsberg OH. Boye NP. Local activation of the coagulation and fibrinolysis systems in lung disease. Thromb Res 1990;57(6):827-38.

Rostagno C, Prisco D, Boddi M, Poggesi L. Evidence for local platelet activation in pulmonary vessels in patients with pulmonary hypertension secondary to chronic obstructive pulmonary disease. Eur Respir J 1991;4(2):147-51.

Barnes PJ, Celli BR. Systemic manifestations and comorbidities of COPD. Eur Respir J 2009;33(5):1165-85.

Agustí A, Edwards LD, Rennard SI, MacNee W, Tal-Singer R, Miller BE, et al. Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype. PLoS One 2012;7(5):e37483.

Shen D, Wang Y. Effects of hypoxia on platelet activation in pilots. Aviat Space Environ Med 1994;65(7):646-8.

Segall M, Goetzman B. Hypoxic pulmonary hypertension: changes in platelet size and number. Am J Perinatol 1991;8(5):300-3.

Vestbo J, Hurd SS, Agustí AG, Jones PW, Vogelmeier C, Anzueto A, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2013;187(4):347-65.

Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2007;176(6):532-55.

Erden EŞ, Dokuyucu R, Demirköse M, Yengil E, Sefil F, Bilgiç HK, et al. Kronik obstrüktif akciğer hastalığının akut alevlenme ve stabil dönemlerinde ortalama trombosit hacminin incelenmesi. J Clin Exp Invest 2013;4(4):483-7.

Bansal R, Gupta HL, Goel A, Yadav M. Association of increased platelet volume in patients of chronic obstructive pulmonary disease: clinical implications. Journal Indian Academy of Clinical Medicine 2002;3(2):169-72.

Tuncel T, Uysal P, Hocaoglu AB, Erge DO, Karaman O, Uzuner N. Change of mean platelet volume values in asthmatic children as an inflammatory marker. Allergol Immunopathol (Madr) 2012;40(2):104-7.

Ulasli SS, Ozyurek BA, Yilmaz EB, Ulubay G. Mean platelet volume as an inflammatory marker in acute exacerbation of chronic obstructive pulmonary disease. Pol Arch Med Wewn 2012;122(6):284-90.

Coban E, Adanir H. Platelet activation in patients with Familial Mediterranean Fever. Platelets 2008;19(6):405-8.

Arica S, Ozer C, Arica V, Karakus A, Celik T, Gunesacar R. Evaluation of the mean platelet volume in children with familial Mediterranean fever. Rheumatol Int 2011;32(11):3559-63.

Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996;7(2):157-61.

Becchi C, Al Malyan M, Fabbri LP, Marsili M, Boddi V, Boncinelli S. Mean platelet volume trend in sepsis: is it a useful parameter? Minerva Anestesiol 2006;72(9):749-56.

Çevik C, Yengil E, Akbay E, Arlı C, Gülmez Mİ, Akoğlu E. Comparison of mean platelet volume values between patients with nasal polyp and healthy individuals. Turk Arch Otolaryngol 2013;51(4):106-9.

Erden EŞ, Yengil E, Tuncel E, Bilgiç HK, Demirköse M, Motor S, et al. Obstrüktif uyku apne sendromu ile ortalama trombosit hacmi arasındaki ilişkinin incelenmesi. J Clin Exp Invest 2013;4(4):492-96.