Our results for five years of rotavirus vaccination

Beş yıllık rotavirüs aşı sonuçlarımız

Abstract

We aimed to evaluate the results of 5 years of rotavirus vaccination experience and compare the effects of monovalent and pentavalent vaccines. This retrospective study included 2345 children vaccinated in a trial that was held between January 2007 and January 2012. Information was obtained on whether the patient was administered the monovalent or pentavalent vaccine, whether he/she had rotavirus gastroenteritis after the vaccination, and whether he/she was treated as an outpatient or an inpatient. This information was obtained from the computer records and, in cases where information was lacking, the families were called to obtain missing details. In all patients with complaints of diarrhea, rotavirus antigen analysis was done with a rapid immunochromatographic stool test. The age range of the children was 3–60 months. Of the patients included in the study, 1270 (54%) were female and 1075 (46%) male. The monovalent vaccine was administered to 1700 (72.5%) children, while the pentavalent vaccine was administered to 645 (27.5%) children. After administration of the vaccine, no major complications were reported. Symptomatic rotavirus gastroenteritis was detected in 4 % of vaccinated children. No patients died due to rotavirus infection. There was no statistically significant difference between the vaccines in terms of the incidence of rotavirus gastroenteritis and the number of children who were hospitalized or received outpatient treatment (P > 0.05). Symptomatic rotavirus gastroenteritis was detected in only 4 % of the vaccinated children in our study. Moreover, there is no significant difference in the protection offered by the monovalent and pentavalent vaccines.