A rare cause of basal ganglia calcification: Down syndrome: Bazal gangliyon kalsifikasyonun nadir bir nedeni: Down sendromu

Sedat Işıkay

doi:10.5455/GMJ-30-151703

Authors

Sedat Işıkay Gaziantep Children's Hospital, Pediatric Neurology Clinic, Gaziantep, Turkey

DOI:

https://doi.org/10.5455/GMJ-30-151703

Keywords:

Basal ganglia calcification, child, Down syndrome

Abstract

Down syndrome, the most common chromosomal abnormality, may be associated with various neurologic complications such as mental retardation, epilepsy, and basal ganglia calcification. Basal ganglia calcification is a rare complication which can be determined in children with Down syndrome. Herein, we have reported a case of Down syndrome in a 6-year-old boy presented with epilepsy, and basal ganglia calcification. In conclusion, patients with Down syndrome should be suspected for the presence of other neurologic disorders.

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References

Harrington MG, Macpherson P, McIntosh WB, Allam BF, Bone I. The significance of the incidental finding of basal ganglia calcifi¬cation on computed tomography. J Neurol Neurosurg Psychiatry 1981;44(12):1168-70.

Thase ME. Basal ganglia calcification and psychosis in Down’s syndrome. Postgrad Med J 1984;60(700):137-9.

Mann DM. Calcification of the basal ganglia in Down’s syndrome and Alzheimer’s disease. Acta Neuropathol 1988;76(6):595-8.

Takashima S, Becker LE. Basal ganglia calcification in Down’s syndrome. J Neurol Neurosurg Psychiatry 1985;48(1):61-4.

Wisniewski KE, French JH, Rosen JF, Kozlowski PB, Tenner M, Wisniewski HM. Basal ganglia calcification (BGC) in Down’s syndrome (DS)--another manifestation of premature aging. Ann N Y Acad Sci 1982;396:179-89.

Okano S, Takeuchi Y, Kohmura E, Yoshioka H, Sawada T. Globus pallidus calcification in Down syndrome with progressive neurologic deficits. Pediatr Neurol 1992;8(1):72-4.

Verulashvili IV, Glonti LSh, Miminoshvili DK, Maniia MN, Mdivani KS. Basal ganglia calcification: clinical manifestations and diagnostic evaluation. Georgian Med News 2006;140:39-43.

Gobbi G. Coeliac disease, epilepsy and cerebral calcifications. Brain Dev 2005;27(3):189-200.

Işıkay S, Kocamaz H. Prevalence of celiac disease in children with idiopathic epilepsy in southeast of Turkey (Celiac disease in children with idiopathic epilepsy). J Pediatr Neurol 2014 (in press).

Jamil K, Abdul Rashid AH, Ibrahim S. Hip dislocation in Down syndrome. J Pediatr Orthop B 2014;23(2):204.

Lee KY, Lee KS, Weon YC. Asymptomatic moyamoya syndrome, atlantoaxial subluxation and basal ganglia calcification in a child with Down syndrome. Korean J Pediatr 2013;56(12):540-3.

Faria PF, Nicolau JA, Melek MZ, Oliveira ND, Bermudez BE, Nisihara RM. Association between congenital heart defects and severe infections in children with Down syndrome. Rev Port Cardiol 2014;33(1):15-8.

Ellis H. John Langdon Down: Down's syndrome. J Perioper Pract 2013;23(12):296-7.

Malak R, Kotwicka M, Krawczyk-Wasielewska A, Mojs E, Samborski W. Motor skills, cognitive development and balance functions of children with Down syndrome. Ann Agric Environ Med 2013;20(4):803-6.

Mårild K, Stephansson O, Grahnquist L, Cnattingius S, Söderman G, Ludvigsson JF. Down syndrome is associated with elevated risk of celiac disease: a nationwide casecontrol study. J Pediatr 2013;163(1):237-42.