Which is Best for Predicting Uveitis in Behc¸et’s Syndrome: Systemic Immune Inflammatory Index, Mean Platelet Volume, Platelet/Lymphocyte Ratio, or Neutrophil/Lymphocyte Ratio?

Abstract

Objective: Behc¸et’s Syndrome (BS) is a multisystemic disease characterized by oral and genital ulcers, which can cause vasculitis that can affect all size of the vessels. We aimed to investigate the power of predicting uveitis of neutrophil/lymphocyte ratio (NLR), platelet/ lymphocyte ratio (PLR), mean platelet volume (MPV) and a new parameter, the systemic inflammatory immune index (SII). Methods: Two hundred four patients with BS were enrolled at Kayseri City Education and Research Hospital, whose follow-up continued from July 2018-September 2020. Thirty-three patients were excluded because of history of cancer, colchicine use, arthritis at the time of diagnosis and complete blood count parameters being excessively higher or lower than the limit values. Of the remaining 171 patients, 35 uveitis patients’ NLR, PLR, MPV and SII at the time of uveitis were compared with the results of patients without uveitis. Results: The sensitivity of NLR in predicting uveitis was calculated as 74.3% and specificity was 64.7%. The sensitivity and specificity of SII, in predicting uveitis, were 62.9% and 65.4%, respectively. The area under the ROC curve for NLR was 0.684 and (P = 0.001). In addition, the area under the curve for SII was 0.662 (P = 0.003). Again for PLR and MPV, the area under the ROC curve was found as 0.566 and 0.428, respectively (P = 0.188 and 0.230, respectively). Conclusion: There is no specific test that can precisely predict BS and its complications. . These findings suggest that NLR is a better marker than SII, MPV and PLR in predicting anterior uveitis in patients with BS.