Mean platelet volume (MPV): could it be used as a predictive marker for gestational diabetes?

Gestasyonel diyabet için ortalama trombosit hacmi (MPV) bir marker olarak kullanılabilir mi?


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Authors

  • Fevzi Balkan Aksaray State Hospital, Endocrinology Clinic, Aksaray, Turkey
  • Celil Alper Usluoğulları Dr. Ersin Arslan State Hospital, Endocrinology Clinic, Gaziantep, Turkey
  • Rıfkı Üçler Yüzüncü Yıl University, Faculty of Medicine, Department of Endocrinology and Metabolic Diseases, Van, Turkey
  • Betül Usluoğulları Gaziantep Cengiz Gökçek Obstetrics and Gynecology Hospital, Obstetrics Clinic, Gaziantep, Turkey
  • Sedat Caner Hacettepe University, Faculty of Medicine, Department of Endocrinology and Metabolic Diseases, Ankara, Turkey

DOI:

https://doi.org/10.5455/GMJ-30-47536

Keywords:

Gestational diabetes, mean platelet volume, pregnancy

Abstract

An abnormal glucose tolerance which is first detected during pregnancy and disappears after completion of pregnancy is known as “gestational diabetes mellitus”. Early detection of this condition helps preventing potential maternal and fetal complications. Some studies reported that platelets may have a role in the pathogenesis and development of gestational diabetes. In the present study, we aimed to evaluate and compare the platelet function and morphology among pregnant women with gestational diabetes and healthy pregnant women. Values of complete blood count were reviewed for pregnant women between weeks 24 and 28 of gestation while performing oral glucose tolerance tests for from January 2013 to September 2013. After screening, a total of 89 pregnant women were enrolled in the study including 38 women with gestational diabetes and 51 healthy pregnant women. The mean platelet volume (MPV) was 8.76 ± 1.53 fl in the group with gestational diabetes and 7.80 ± 1.34 fl in the healthy pregnant group, with a statistically significant difference between two groups (P=0.02). There was no statistically significant difference between two groups in platelet counts (P=0.25). Dissimilar results were reported by a small number of studies on this subject. MPV and other platelet parameters may be considerably helpful in detecting diabetic pregnant women who are at risk for vascular complications. In this study, significantly greater MPV was found among pregnant women with gestational diabetes compared to control group (P<0.05). Further studies are needed to elucidate the role of such changes and their potential clinical implications in women with gestational diabetes.

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References

Turok DK, Ratcliffe SD, Baxley AG. Management of gestational diabetes mellitus. Am Fam Physician 2003; 68(9):1767-72.

Kim C, Tabaei BP, Burke R, McEwen LN, Lash RW, Johnson SL, et al. Missed opportunities for type 2 diabetes mellitus screening among women with a history of gestational diabetes mellitus. Am J Public Health 2006; 96(9):1643-8.

Guariguata L, Linnenkamp U, Beagley J, Whiting DR, Cho NH. Global estimates of the prevalence of hyperglycaemia in pregnancy for 2013 for the IDF Diabetes Atlas. Diabetes Res Clin Pract 2013.

Pöyhönen-Alho M, Joutsi-Korhonen L, Lassila R, Kaaja R. Alterations of sympathetic nervous system, coagulation and platelet function in gestational diabetes. Blood Coagul Fibrinolysis 2012; 23(6):508-13.

Stein PD, Goldman J, Matta F, Yaekoub AY. Diabetes mellitus and risk of venous thromboembolism. Am J Med Sci 2009; 337(4): 259-64.

Erikçi AA, Muhçu M, Dündar O, Oztürk A. Could mean platelet volume be a predictive marker for gestational diabetes mellitus? Hematology 2008;13(1): 46-8.

Bancroft AJ, Abel EW, Mclaren M, Belch JJ. Mean trombosit volume is a useful parameter: a reproducible routine method using a modified Coulter thrombocytometer. Trombosits 2000;11(7):379-87.

Senaran H, Ileri M, Altinbaş A, Koşar A, Yetkin E, Oztürk M, et al. Thrombopoietin and mean trombosit volume in coronary artery disease. Clin Cardiol 2001;24(5):405-8.

Winocour PD. Platelet turnover in advanced diabetes. Eur J Clin Invest 1994;24 (Suppl 1):34-7.

Pizulli L, Yang A, Martin JF, Lüderitz B. Changes in platelet size and count in unstable angina compared to stable angina or non-cardiac chest pain. Eur Heart J 1998;19(1):80-4.

Vignini A, Moroni C, Nanetti L, Raffaelli F, Cester A, Gabrielli O, et al. Alterations of platelet biochemical and functional properties in newly diagnosed type 1 diabetes: a role in cardiovascular risk? Diabetes Metab Res Rev 2011; 27(3): 277-85.

Hekimsoy Z, Payzin B, Ornek T, Kandoğan G. Mean platelet volume in Type 2 diabetic patients. J Diabetes Complications 2004;18(3):173-6.

Coban E, Bostan F, Ozdogan M. The mean platelet volume in subjects with impaired fasting glucose. Platelets 2006;17(1):67-9.

Bozkurt N, Yilmaz E, Biri A, Taner Z, Himmetoğlu O. The mean platelet volume in gestational diabetes. J Thromb Thrombolysis 2006;22(1):51-4.

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Published

2023-05-02

How to Cite

Balkan, F., Usluoğulları, C. A., Üçler, R., Usluoğulları, B., & Caner, S. (2023). Mean platelet volume (MPV): could it be used as a predictive marker for gestational diabetes? Gestasyonel diyabet için ortalama trombosit hacmi (MPV) bir marker olarak kullanılabilir mi?. European Journal of Therapeutics, 20(2), 123–125. https://doi.org/10.5455/GMJ-30-47536

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