The role of human papillomavirus-16 and matrix  metalloproteinase-9 in pathogenesis of uterine cervical  neoplasia : Uterus servikal neoplazi patogenezinde insan papillomavirüs-16 ve matriks  metalloproteinaz-9’un rolü

Areej Atiyah Hussein; Hujaz Ismail Abdulrazzaq; Haider Sabah Kadhim

doi:10.5455/GMJ-30-2012-82

Authors

Areej Atiyah Hussein Diyala University, College of Medicine, Diyala
Hujaz Ismail Abdulrazzaq Baghdad University, Al-Kindi College of Medicine, Baghdad
Haider Sabah Kadhim Al-Nahrain University, College of Medicine, Al-Kadhimiya

DOI:

https://doi.org/10.5455/GMJ-30-2012-82

Keywords:

HPV-16, invasion, matrix metalloproteinases, metastasis, uterine cervical neoplasia

Abstract

Uterine cervical neoplasia is a major health problem, and can be a leading cause of death. There is strong evidence that human papillomavirus (HPV) is the principal etiological agent in cervical neoplasia. The objective of this study was to investigate the correlation between HPV-16 and matrix metalloproteinase-9 (MMP-9) and uterine cervical neoplasia. Twenty six formalin fixed, paraffin embedded specimens from patients with uterine cervical neoplasia from teaching laboratories in Baghdad city, were included in this study. In addition fifteen apparently normal cervical tissue blocks have been obtained from patients undergoing hysterectomies for sustained uterine bleeding used as control group. In situ hybridization analysis was performed with cDNA probes to HPV-16 and MMP-9. The expression of HPV-16 and MMP-9 in uterine cervical neoplasia cases in the present study was 50% and 61% respectively, but relationship was not found between expression of HPV-16 and MMP-9 and uterine cervical neoplasia. In conclusion, HPV-16 and MMP-9 may have an essential role in progression of uterine cervical neoplasia.

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