Tamoxifen-induced hepatic steatosis in premenopausal breast cancer patients

Premenapozal meme kanserli hastalarda tamoksifene bağlı hepatosteatoz


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Authors

  • Mustafa Yıldırım Antalya Education and Research Hospital, Department of Medical Oncology, Antalya
  • Eda Parlak Antalya Education and Research Hospital, Department of Radiology, Antalya
  • Dinç Süren Antalya Education and Research Hospital, Department of Pathology, Antalya
  • Utku Dönem Dilli Antalya Education and Research Hospital, Department of Medical Oncology, Antalya
  • Sevil Göktaş Antalya Education and Research Hospital, Department of Medical Oncology, Antalya
  • Çetin Kaya Antalya Education and Research Hospital, Department of Medical Oncology, Antalya
  • Mustafa Yıldız Antalya Education and Research Hospital, Department of Medical Oncology, Antalya
  • Mustafa Yıldız Antalya Education and Research Hospital, Department of Medical Oncology, Antalya

DOI:

https://doi.org/10.5455/GMJ-30-2011-50

Keywords:

Breast cancer, hepatosteatosis, tamoxifen

Abstract

While aromatase inhibitors are replacing tamoxifen in postmenopausal breast cancer patients, tamoxifen continues to be the first-line hormonal therapy in premenopausal patients. Tamoxifen-induced hepatosteatosis may lead to nonalcoholic steatohepatitis (NASH), and NASH may develop into cirrhosis. If the development of hepatosteatosis is predicted, these patients may be treated with fibrates and statins. This study examines the development of hepatosteatosis in our premenopausal breast cancer patients that were taking tamoxifen for adjuvant therapy and were positive for the hormone receptors. Patients histopathologically diagnosed with breast cancer and with immunohistochemically demonstrated estrogen and/or progestron receptor expression were recruited for the study. All patients were assessed with ultrasonography by the same radiologist before tamoxifen therapy, at the sixth month of the follow-up and at the end of the first year. The study results were evaluated in thirty patients. Initial ultrasonography revealed grade 2 hepatosteatosis in four patients (13.3%), no change occurring at the repeat ultrasonography performed at the sixth month of the follow-up. Seven patients (23. 3%) were diagnosed as having grade 1 hepatosteatosis. A total of 12 patients (40%) were found to have hepatosteatosis at the end of the first year. Findings at the outset and those at the end of the first year were significantly different (p=0.021) as determined with the Wilcoxon test and Bonferroni correction performed to ascertain the difference in hepatosteatosis between the outset and the follow-up periods. No difference was obtained between the findings for the sixth month and those obtained at the end of the first year. In conclusion, the rate of hepatosteatosis as assessed with ultrasonography shows an increase with tamoxifen use in premenopausal patients. There was no difference between ultrasonography findings at the end of the first year and those at the sixth month of the follow-up. We think that the sitxh-month ultrasonography bears importance from the viewpoint of hepatosteatosis in these patients.

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Published

2023-05-02

How to Cite

Yıldırım, M., Parlak, E., Süren, D., Dilli, U. D., Göktaş, S., Kaya, Çetin, Yıldız, M., & Yıldız, M. (2023). Tamoxifen-induced hepatic steatosis in premenopausal breast cancer patients: Premenapozal meme kanserli hastalarda tamoksifene bağlı hepatosteatoz. European Journal of Therapeutics, 17(3), 133–136. https://doi.org/10.5455/GMJ-30-2011-50

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