Kimura’s disease an unusual cause of lymphadenopathy in a nephrotic syndrome child: Nefrotik sendromlu bir çocukta lenfadenopatinin olağandışı nedeni olarak Kimura  hastalığı

Chenthilnathan Periasamy; Norzaliana Zawawi; Md Salzihan Md Salleh; Baharudin Abdullah

doi:10.5455/GMJ-30-2012-71

Authors

Chenthilnathan Periasamy Universiti Sains Malaysia, School of Medical Sciences, Department of Otolaryngology-Head and Neck Surgery, Kubang Kerian, Kelantan
Norzaliana Zawawi Universiti Sains Malaysia, School of Medical Sciences, Department of Pathology, Kubang Kerian, Kelantan
Md Salzihan Md Salleh Universiti Sains Malaysia, School of Medical Sciences, Department of Pathology, Kubang Kerian, Kelantan
Baharudin Abdullah Universiti Sains Malaysia, School of Medical Sciences, Department of Otolaryngology-Head and Neck Surgery, Kubang Kerian, Kelantan

DOI:

https://doi.org/10.5455/GMJ-30-2012-71

Keywords:

Immunoglobulin E, Kimura’s disease, lymphadenopathy, nephrotic syndrome, peripheral eosinophilia

Abstract

Kimura’s disease is a rare, benign, chronic inflammatory disorder of unknown etiology which is endemic in Orientals. The disease is characterized by a triad of painless subcutaneous nodule in the head and neck region, blood eosinophilia and elevated serum immunoglobulin E (IgE) levels. Kimura’s disease has various synonyms such as eosinophilic lymphogranuloma, inflammatory angiomatous nodule and atypical pyogenic granuloma. Renal pathology such as nephrotic syndrome has been found to be associated with Kimura’s disease which states a common etiopathogenesis between renal lesion and Kimura’s disease. We present an eleven years old Malay boy with recurrent nephrotic syndrome presented with left post auricular swelling. The diagnosis was based on the characteristic histopathology findings after surgical biopsy as Kimura’s disease.

Metrics

Metrics Loading ...

References

Goldenberg D, Gatot A, Barki Y, Leiberman A, Fliss DM. Computerized tomographic and ultrasonographic features of Kimura's disease. J Laryngol Otol 1997;111(4):389-91.

Kung IT, Gibson JB, Bannatyne PM. Kimura's disease: a clinico-pathological study of 21 cases and its distinction from angiolymphoid hyperplasia with eosinophilia. Pathology 1984;16(1):39-44.

Ranka SR, Rajput A, Kantharia CV. Kimura’s disease. A Case Report. Indian J Otolaryngol Head Neck Surg 2004;56(1):43-5.

Yuen HW, Goh YH, Low WK, Lim-Tan SK. Kimura's disease: a diagnostic and therapeutic challenge. Singapore Med J 2005;46(4):179-83.

Matsuda O, Makiguchi K, Ishibashi K, Chida Y, Ida T, Matsuda K, et al. Long-term effects of steroid treatment on nephrotic syndrome associated with Kimura's disease and a review of the literature. Clin Nephrol 1992;37(3):119-23.

Yamada A, Mitsuhashi K, Miyakawa Y, Kosaka K, Takehara K, Iijima M, et al. Membranous glomerulonephritis associated with eosinophilic lymphfolliculosis of the skin (Kimura's disease): report of a case and review of the literature. Clin Nephrol 1982;18(4):211-5.

Whelan TV, Maher JF, Kragel P, Dysart N, Dannenhoffer R, Prager L. Nephrotic syndrome associated with Kimura's disease. Am J Kidney Dis 1988;11(4):353-6.

Atar S, Oberman AS, Ben-Izhak O, Flatau E. Recurrent nephrotic syndrome associated with Kimura's disease in a young non-Oriental male. Nephron 1994;68(2):259-61.

Chen H, Thompson LD, Aguilera NS, Abbondanzo SL. Kimura disease: a clinicopathologic study of 21 cases. Am J Surg Pathol 2004;28(4):505-13.

Kuo TT, Shih LY, Chan HL. Kimura's disease. Involvement of regional lymph nodes and distinction from angiolymphoid hyperplasia with eosinophilia. Am J Surg Pathol 1988;12(11):843-54.

Gumbs MA, Pai NB, Saraiya RJ, Rubinstein J, Vythilingam L, Choi YJ. Kimura's disease: A case report and literature review. J Surg Oncol 1999;70(3):190-3.

Deshpande AH, Nayak S, Munshi MM, Bobhate SK. Kimura's disease. Diagnosis by aspiration cytology. Acta Cytol 2002;46(2):357-63.

Chartapisak W, Opastirakul S. Steroid-resistant nephrotic syndrome associated with Kimura’s Disease. Am J Nephrol 2002;22(4):381-4.

Asma A, Maizaton AA. Kimura’s disease: an unusual cause of cervical tumor. Med J Malaysia 2005;60(3):373-6.

Sud K, Saha T, Das A, Kakkar N, Jha V, Kohli HS, et al. Kimura’s disease and minimal-change nephrotic syndrome. Nephrol Dial Transplant 1996;11(7):1349-51.

Shahrul H, Baharudin A, Effat O. Kimura’s disease in Malay patients. Med J Malaysia 2007;62(3):263-4.