The effect of the glucose-insulin-potassium solution on the p-wave dispersion of the  heart failure patients : Kalp yetersizliği hastalarında glukoz-insülin-potasyum infüzyonunun p dalga dispersiyonu üzerine etkisi

Süleyman Ercan; Muhammed Oylumlu; Mustafa Oylumlu; Serdar  Soydinç; Vedat  Davutoğlu

doi:10.5455/GMJ-30-2012-91

Authors

Süleyman Ercan Gaziantep Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Gaziantep
Muhammed Oylumlu Gaziantep Şehitkamil Devlet Hastanesi, Kardiyoloji Kliniği, Gaziantep
Mustafa Oylumlu Dicle Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Diyarbakır
Serdar Soydinç Dicle Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Diyarbakır
Vedat Davutoğlu Gaziantep Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Gaziantep

DOI:

https://doi.org/10.5455/GMJ-30-2012-91

Keywords:

Glucose-insulin-potassium, heart failure, P wave dispersion

Abstract

Atrial fibrillation (AF) has adverse effects on the disease prognosis and the functional capacity during heart failure. P wave dispersion has been considered as one of the most important parameters predicting the development of AF. It is known that glucose-insulinpotassium (GIK) infusion has favorable metabolic and hemodynamic effects. The aim of our study is to investigate the effects of GIK infusion on P wave dispersion in patients with heart failure. In our study, 30 patients with the diagnosis of heart failure and a low left ventricular ejection fraction (EF<40%) were included. Fifteen patients randomized to GIK solution (20 U insulin and 60 mEq KCl in 20% 500 ml dextrose solution) in 8 hours for consecutive 3 days (Group I) and other 15 patients were randomized to isotonic NaCl solution in addition to the conventional therapy (Group II, control). Twelve-lead electrocardiography were recorded in all patients to detect the P wave dispersion. P wave dispersion was calculated between the Group I and Group II patients before the study respectively (19.4±7.5 and 19±6.3) (p>0.05). In Group I, P wave dispersion measured after GIK infusion was 13 ± 6.5. In group II, P wave dispersion measured after 0.9% NaCl solution infusion were 20.4±6.4. P wave dispersion was found significantly lower in patients administrated GİK infusion (p=0.001). According to the present study, we showed that the P wave dispersion which predicts AF was significantly lower in the patients treated with GIK than in the control group.

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