Immunological and clinical progress of HIV-infected  patients on highly active antiretroviral therapy in north  west Ethiopia: Kuzey Batı Etiyopya’da yüksek etkili antiretroviral tedavi alan HIV-enfekte  hastaların immünolojik ve klinik gelişimi

Nasir Tajure Wabe; Mohammed Alemu

doi:10.5455/GMJ-30-2011-65

Authors

Nasir Tajure Wabe Clinical Pharmacy Unit, Department of Pharmacy, College of Public Health and Medical Science, Jimma University, Jimma
Mohammed Alemu Clinical Pharmacy Unit, Department of Pharmacy, College of Public Health and Medical Science, Jimma University, Jimma

DOI:

https://doi.org/10.5455/GMJ-30-2011-65

Keywords:

CD4 count, clinical progress, HAART, immunological progress

Abstract

The survival benefits of highly active antiretroviral therapy (HAART) in HIV infected patients have been studied well in the developed world. In resource poor settings like Ethiopia such treatment was started only in 2003. As a result, the existing treatment guidelines and recommendations are based on data from the developed world. The objective of this study was to determine the immunological and clinical progress in HIV/AIDS patients in one year data review of patients’ card who initiated on HAART in Ethiopia. A retrospective cohort study was done based on past medical records of HIV/AIDS patients, using a structured data collection format. All patient cards of one year data with patients who initiated HAART from October 1, 2006 to November 30, 2007 were included in the study. The data collected was analyzed using SPSS for window version 16.0. The majority of the study population (383, 64.2%) were prescribed zidovudine/lamivudine/neverapine (ZDV/3TC/NVP) regimen initially. Overall functional status change showed that ability to work was increased by 31.5%, being ambulatory decreased by 93.4% and bedridden status decreased by 80%. A total of 240 (46.9%) patients have showed functional status improvement. Average mean weight change of 5.9 kg (increment by 11.9%) was seen during a one year follow-up. The patients showed immunological change from 132.883 mean CD4/mm3 count to 335.87 mean CD4/mm3 . About 492 (82.4%) patients present with different type of opportunistic infections (OIs) at start of therapy which dramatically dropped to only 40 (6.7%) patient after one year of receiving HAART. HAART initiation has decreased progression of the diseases and improved the patients’ quality of life. Most patients have showed a significant increment in their CD4 count. The restoration of CD4 in turn has improved the clinical status of most patients. Despite the significant progression of health of patients, greater immunological and clinical success should be attained by encouraging patients for effective use of those lifesaving drugs with maximal adherence.

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