mRNA Expressions of SOCS3 Gene in Meningitis Patients

Serdar Öztuzcu; Ahmet  Arslan; Ercan Sivaslı; Mustafa Namıduru; Yusuf Ziya İğci; Esma Özkara; Mehri İğci; Zeynep Eşlik; Recep Bayraktar; Ecir Ali Çakmak; Mehmet Yavuz Coşkun

doi:10.58600/eurjther.2011-17-1-747-arch

Authors

Serdar Öztuzcu Gaziantep Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Gaziantep
Ahmet Arslan Gaziantep Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Gaziantep
Ercan Sivaslı Gaziantep Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Gaziantep
Mustafa Namıduru Gaziantep Üniversitesi, Tıp Fakültesi, Enfeksiyon Hastalıkları ve Klinik Bakteriyoloji Anabilim Dalı, Gaziantep
Yusuf Ziya İğci Gaziantep Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Gaziantep
Esma Özkara Gaziantep Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Gaziantep
Mehri İğci Gaziantep Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Gaziantep
Zeynep Eşlik Gaziantep Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Gaziantep
Recep Bayraktar Gaziantep Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Gaziantep
Ecir Ali Çakmak Gaziantep Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Gaziantep
Mehmet Yavuz Coşkun Gaziantep Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Gaziantep

DOI:

https://doi.org/10.58600/eurjther.2011-17-1-747-arch

Keywords:

Meningitis, Real Time PCR, SOCS3

Abstract

Meningitis is an inflammatory disease caused by microorganisms and viruses with various clinical symptoms, which damages the brain tissue and membranes, and which induces biochemical and cellular changes in cerebrospinal fluid (CSF). Meningitis is an infectious disease with higher rates of mortality and morbidity. The possibility of death or permanent damage to patient is considerable, mortality rate is one in ten patients and permanent damages like deafness or various brain damages are one in seven patients. Experimental animal meningitis revealed that the leukocytes infiltrated in CSF due to bacterial dissemination contributed to damage progression in brain tissue, increased brain edema and intracranial pressure. The association between gene expression of SOCS3 which is effective in repressing the JAK/STAT signal transduction pathway and meningitis disease were investigated in this study. Gene expression levels of SOCS3 in leukocytes leaked to CSF were investigated by using real-time PCR method in this study. As a result of our study, there was no difference in blood SOCS3 gene expression levels between meningitis patients and healthy controls (p>0.05). Additionally, there was no meaningful difference between SOC3 gene expression of blood and CSF samples in meningitis patients (p>0.05). Our data suggests that further molecular studies are needed and important in meningitis disease diagnosis and treatment, and in the other genes responsible for repressing of inflammatory development.

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