Vitamin K and Osteoporosis

Emine Siber Namıduru; Mehmet Tarakçıoğlu

doi:10.58600/eurjther.2011-17-1-739-arch

Authors

Emine Siber Namıduru Gaziantep Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Gaziantep
Mehmet Tarakçıoğlu Gaziantep Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Gaziantep

DOI:

https://doi.org/10.58600/eurjther.2011-17-1-739-arch

Keywords:

Vitamin K, osteoporosis, osteocalcin, fracture risk

Abstract

Vitamin K is involved in blood coagulation and in bone metabolism via the carboxylation of glutamate residues in (hepatic) blood coagulation factors and (osteoblastic) bone proteins. Although undercarboxylation of blood coagulation factors is very rare, undercarboxylated osteocalcin (bone Gla-protein) is frequently found in subject with osteoporosis. Osteoporosis, a systemic disease characterized by a low bone mass, is a major public health problem. It is a devastating disorder with significant physical, psychosocial, and financial problems because of the high incidence of fragility fractures, especially hip and vertebral fracture. The high incidence of osteoporotic fractures leads to considerable mortality, morbidity, reduced mobility and decreased quality of life. Hence one of the most important approaches to therapy is prevention. Supplementation of osteoporotic subjects with extra vitamin K causes the markers for bone formation to increase. In parallel, a decrease of the markers for bone resorption is frequently seen, Because of vitamin K can be decreased the risk of developing osteoporosis and its complications can be minimized. In this review summarizes with a theoretical knowledge about vitamin K and osteoporosis plus current reports regarding a possible role of vitamin K insufficiency in the pathogenesis of osteoporosis.

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