Relation of left atrial volume index with subclinical atherosclerosis at patients with  metabolic syndrome: Metabolik sendromlu hastalarda sol atriyal volüm  indeksi’nin subklinik ateroskleroz ile ilişkisi

Ali Rıza Gülcan; Mustafa Serkan Karakaş; Refik Emre Altekin; Sinan Cemgil Özbek; Barış Akdemir; Hüseyin Yılmaz

doi:10.5455/GMJ-30-2012-107

Authors

Ali Rıza Gülcan Şanlıurfa Eğitim ve Araştırma Hastanesi Kardiyoloji Kliniği, Şanlıurfa
Mustafa Serkan Karakaş Niğde Devlet Hastanesi Kardiyoloji Kliniği, Niğde
Refik Emre Altekin Akdeniz Üniversitesi Tıp Fakültesi Kardiyoloji Anabilim Dalı, Antalya
Sinan Cemgil Özbek Kırşehir Ahi Evran Üniversitesi Eğitim ve Araştırma Hastanesi Kardiyoloji Kliniği, Kırşehir
Barış Akdemir Akdeniz Üniversitesi Tıp Fakültesi Kardiyoloji Anabilim Dalı, Antalya
Hüseyin Yılmaz Akdeniz Üniversitesi Tıp Fakültesi Kardiyoloji Anabilim Dalı, Antalya

DOI:

https://doi.org/10.5455/GMJ-30-2012-107

Keywords:

Carotis intima-media thickness, diastolic dysfunction, left atrial volume index, subclinical atherosclerosis, metabolic syndrome

Abstract

Metabolic syndrome (MetS) increases the frequency of cardivovascular events by causing atherosclerosis and impairment at left ventricle structure and function. Diastolic dysfunction (DD) is an early finding of subclinical cardiac injury. Left atrial volume may be used as an indicator for demonstrating severity and duration of DD. With this study, we investigated the relationship between subclinical atherosclerosis ,evaluated by carotid intima-media thickness (CIMT) measurement and subclinical cardiac injury evaluated by diastolic functions and left atrial volume index (LAVI) in MetS patients. 82 patients with MetS were enrolled to the study. Patients were divided into 2 groups according to CIMT measurement: 35 patients with CIMT≥1.0 mm were at group 1 and 47 patients with CIMT<1.0 mm were at group 2. Systolic and diastolic functions were evaluated, LAVI was calculated. Frequency of DD was found statistically significantly higher in group 1 (p=001). There was no difference between groups for grade I DD and grade (p=0079). LAVI values were calculated as 32.6±6.0 ml/m² and 26.6±4.7 ml/m² at group 1 and 2,respectively.There was a statistically significant difference between two groups.When correlation with LAVI was investigated,a positive correlation with CIMT was observed. When correlation between data from conventional and tissue Doppler imaging and LAVI was evaluated,there were positive correlations for left ventricle mass index, septal and lateral E/Em rates, and negative correlations for septal and lateral Em/Am rates. LAVI was found to be high in-patient with higher CIMT value which is non-invasive indicator of subclinical atherosclerosis. In addition, in all patients, a relation was observed between presence and severity of diastolic dysfunction and increase in LAVI value.

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