The levels of HbA1c in patients with thyroid dysfunction: Tiroid disfonksiyonlu hastalarda HbA1c düzeyleri

Abbas Ali Tam; Hasan Tam; Celil Alper  Usluoğulları; İsa  Dede; Fevzi Balkan; Cafer Kaya; Rıfkı Üçler; Erdal  Eskioğlu

doi:10.5455/GMJ-30-161185

Authors

Abbas Ali Tam Numune Training and Research Hospital, Internal Medicine
Hasan Tam Numune Training and Research Hospital, Family Health Clinics
Celil Alper Usluoğulları Atatürk Training and Research Hospital, Endocrinology and Metabolism Diseases
İsa Dede Numune Training and Research Hospital, Internal Medicine
Fevzi Balkan Atatürk Training and Research Hospital, Endocrinology and Metabolism Diseases
Cafer Kaya Atatürk Training and Research Hospital, Endocrinology and Metabolism Diseases
Rıfkı Üçler Atatürk Training and Research Hospital, Endocrinology and Metabolism Diseases
Erdal Eskioğlu Numune Training and Research Hospital, Internal Medicine

DOI:

https://doi.org/10.5455/GMJ-30-161185

Keywords:

Thyroid dysfunction, HbA1c, Insulin resistance

Abstract

Thyroid hormones increase the hepatic glyconeogenesis, glycogenolysis and the absorption of glucose. Glucose intolerance is common in thyroid dysfunction. HbA1c is the most important determinant of long term glysemic status in diabetic patients. HbA1c is affected from various factors. In this study we evaluated the relation between thyroid function tests and HbA1c in non-diabetic patients with thyroid dysfunction. Non-diabetic 43 patients with hyperthyroidism, 20 patients with hypothyroidism and for control group 29 euthyroid patients which appealed to Ankara Numune Training and Research Hospital Internal Outpatient Clinic between June 2008 and January 2009 were recruited to this study. Fasting blood sugar, urea, creatinine, hemoglobine, HbA1c, TSH, FT3, FT4 and albumine levels of all of the patients that recruited to study were determined. There was no statistically significant difference for the mean age (p=0.271) and gender distribution (p=0.23) in the cases of hyperthyroidism, hypothyroidism and euthyroid controls. HbA1c levels were significantly higher in hyperthyroid group when compared to hypothyroid and euthyroid groups (p<0,001). Fasting blood glucose levels were found significantly higher in hyper thyroid group than hypothyroid and euthyroid groups (p=0.018). A positive correlation was revealed between the increasing age and HbA1c levels. A statistically significant difference was found in the levels of HbA1c values in patients with hyperthyroidism according to euthyroid and hypothyroid patients and this finding is in compliance with the results of current literature. This makes us to think that here is a relation between insulin resistance and hyperthyroidism. Therefore, it is suggested that monitorisation of blood glucose levels regularly is useful for the early diagnose of type II diabetes mellitus in patients with hyperthyroidism, both during the therapy and post treatment period.

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