A new dressing material in diabetic wounds: Wound healing activity of oleuropein-rich olive leaf extract in diabetic rats

Sevgin Samancıoğlu; Aynur Esen; Gülinnaz Ercan; Navid Hosseini Mansoub; Seda Vatansever; İskender İnce

doi:10.5578/GMJ.27960

Authors

Sevgin Samancıoğlu Department of Nursing, Faculty of Health Sciences, Gaziantep University, Gaziantep
Aynur Esen Department of Internal Nursing, Faculty of Nursing, Ege University, Izmir
Gülinnaz Ercan Department of Medical Biochemistry, Faculty of Medicine, Ege University, Izmir
Navid Hosseini Mansoub Department of Medical Biochemistry, Faculty of Medicine, Ege University, Izmir
Seda Vatansever Department of Histology and Embryology, Faculty of Medicine, Celal Bayar University, Manisa
İskender İnce Center for Drug Reseacrh and Development and Pharmacokinetic Applications, Ege University, Izmir

DOI:

https://doi.org/10.5578/GMJ.27960

Keywords:

Diabetes, olive leaf extract, diabetic wound, wound dressing

Abstract

Introduction: The objective of this study was to evaluate a dressing material on ischemic wound model in diabetic rats. Study was conducted during the months of June 2012-March 2013 at Ege University in Izmir, Turkey.
Materials and Methods: Spraque Dawley rats weighing 200-250 g obtained from an experimental animal production center (Saki YeniliAnkara,Turkey) were used in this study. Animals were randomly assigned to diabetic (n= 20) and nondiabetic (n= 20) groups. After diabetes induction and wound creation, animals within each group were assigned to two wound dressing groups by a second randomization. The study was carried out on these four groups. After diabetes induction and wound creation, animals within each group (n= 10) were assigned to olive leaf extract (OLE) wound dressing and normal saline (sodium chloride, 0.9% NaCl) wound dressing groups by a second randomization. 0.9% NaCl and OLE dressing was applied to wounds once a day by the researcher. The areas of wounds were measured by Walker Formula. OLE wound dressing healed wounds faster and earlier than classic wound dressing (p< 0.05).
Results: In the diabetic group; wounds closure time was found to be 24.80 ± 1.48 in OLE wound dressing and 28.00 ± 2.31 days in classical wound dressing.
Conclusion: As a result in terms of success ratios, OLE wound dressing for wound healing in diabetic and non-diabetic wounds has been determined to be more effective in comparison with classic wound dressing method.

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