Oral glucose administration impairs fertility parameters of male albino wistar rats

Uduak Akpan Okon; Ndubuisi Emmanuel Nwachukwu

doi:10.5578/GMJ.27959

Authors

Uduak Akpan Okon Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Uyo, Uyo, AkwaIbom State
Ndubuisi Emmanuel Nwachukwu Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Uyo, Uyo, AkwaIbom State

DOI:

https://doi.org/10.5578/GMJ.27959

Keywords:

Fertility, glucose, sex hormones, male, semen analysis

Abstract

Introduction: Fertility issues has been one of the major concerns of health care givers and the patients; several factors can interfere with fertility parameters. This study was conducted to investigate the effect of glucose on male fertility parameters.
Materials and Methods: Eighteen male albino wistar rats weighing between 220 and 240 g were used. They were randomly assigned into three groups of six rats each. Group one served as control and was gavaged 5 mL of normal rat chow, groups two and three were gavaged 2.5 mg/kg and 5 mg/kg body weight glucose orally, twice daily as medium and high dose respectively twice daily for 21 days. On the 22nd day, the rats were sacrifi ced; blood samples were obtained by cardiac puncture; following standard procedure, the serum was obtained for hormonal (FSH, LH, Prolactin and Testosterone) assay using immunoassay kits. The testes were harvested and semen analysis was done.
Results: The results showed that FSH levels in medium and high dose groups were signifi cantly (p< 0.01) higher. There was a signifi - cant (p< 0.01) dose-dependent decrease in LH levels. A signifi cant (p< 0.01) dose-dependent decrease was observed in sperm motility. Also, a signifi cant (p< 0.01) decrease was observed in percentage sperm concentration and percentage normal sperm morphology.
Conclusion: We therefore infer that excess glucose intake adversely affects male fertility parameters in male albino wistar rats.

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