Factors Affecting Adverse Effects after Kidney Transplantation

Necla Benlier; Hatice Güzel; Medet Korkmaz; Mehmet Fatih Yüzbaşıoğlu

doi:10.5152/EurJTher.2017.281

Authors

Necla Benlier Department of Medical Pharmacology, Sanko University School of Medicine, Gaziantep https://orcid.org/0000-0002-9605-2387
Hatice Güzel Department of Nursing, Sanko University Institute of Health Sciences, Gaziantep https://orcid.org/0000-0001-9388-5247
Medet Korkmaz Department of Nursing, Sanko University Institute of Health Sciences, Gaziantep https://orcid.org/0000-0002-9894-9331
Mehmet Fatih Yüzbaşıoğlu Department of General Surgery, Kahramanmaraş Sütçü Imam University School of Medicine, Kahramanmaraş https://orcid.org/0000-0002-0335-9524

DOI:

https://doi.org/10.5152/EurJTher.2017.281

Keywords:

Kidney transplantation, immunosuppressive therapy, calcineurin inhibitors, side effects, dialysis

Abstract

Objective: The incidence of developing adverse effects in recipients after kidney transplantation (Tx) was analyzed.
Methods: A total of 206 patients (mean age was 41.40±11.88 years, 92.7% were between 46 and 59 years old, and 66.0% were men) who underwent Tx between 2011 and 2016 were evaluated retrospectively. Information regarding the sociodemographic characteristics of the patients was collected using the “Sociodemographic Characteristics Data Collection Form,” which was created by the researcher.
Results: Various adverse effects were detected in 206 patients who participated in our study. The incidence of adverse effects was significantly higher in patients who had hypertension and chronic glomerulonephritis who underwent dialysis treatment during 0–12 months before Tx and who received a kidney transplant from a living donor (p=0.001). The incidence of adverse effects related to the immunosuppressive drugs used after transplantation was significantly higher in patients receiving mycophenolate mofetil (MMF)+steroid+tacrolimus and MMF+steroid+cyclosporine, and weight gain was higher in patients receiving the same group of drugs (p=0.001). There were no significant differences in terms of adverse effects that occurred in other drug combinations.
Conclusion: We found that many factors (e.g., immunosuppressive drugs) in Tx patients may be associated with the incidence of adverse effects.

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