Splanchnic Venous Thrombosis, with Spotlight on Occult Malignancies, Anticoagulation, and Bleeding
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DOI:
https://doi.org/10.5152/EurJTher.2018.483Keywords:
Splanchnic venous thrombosis, anticoagulation, bleeding, malignancyAbstract
Objective: Splanchnic venous thrombosis (SVT) conceptually embraces thrombosis in the portal, hepatic, splenic, and mesenteric venous system thrombosis. The SVT risk factors may be classified as abdominal disorders, underlying myeloproliferative neoplasms (MPN), inherited thrombophilic syndromes, and autoimmune disorders. The aim of our study is to evaluate the risk factors for SVT and their relations with the localization of involvement and anticoagulation during the acute period and relation to major bleeding.
Methods: All patients with portal vein thrombosis or splenic venous thrombosis in their radiologic evaluation report were included over a 5-year period.
Results: Of the 96 patients, 87 had an identifiable risk factor for SVT (90.6%). The major risk factor was cirrhosis (60 patients, 62.5%). Other risk factors included thrombophilic conditions (12 patients, 12.6%), 6 patients had the myeloproliferative disorder (6.3%), and most interestingly, 24 had occult malignancy for which SVT was the presenting factor (25%). Within the whole group, 51 patients (53.1%) received anticoagulant treatment. Within the whole group, 30 patients developed major bleeding (31.3%), and 20 of these patients did not receive anticoagulation therapy. Twenty-five of the patients with cirrhosis suffered bleeding, and 18 of them did not receive anticoagulation therapy.
Conclusion: Almost all patients with SVT had an identifiable risk factor. The follow-up and further treatments should be based on this risk factor. SVT may be the presenting finding of occult malignancies and occult malignancy should be investigated in every patient with SVT. Anticoagulation during the initial acute period should not be withheld, even in patients with the chronic liver disease with a concern for major bleeding.
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References
Rajani R, Almer S. Incidence and prevalence rates in Budd-Chiari syndrome. Gut 2009;58: 889.
Rajani R, Björnsson E, Bergquist A, Danielsson A, Gustavsson A, Grip O, et al. The epidemiology and clinical features of portal vein thrombosis: a multicentre study. Aliment Pharmacol Ther 2010;32: 1154-62.
White RH. The epidemiology of venous thromboembolism. Circulation 2003 Jun 17;107: 14-8.
Primignani M. Portal vein thrombosis revisited. Dig Liver Dis 2010;42: 163-70.
Ageno W, Squizzato A, Togna A, Magistrali F, Mangini M, Fugazzola C, et al. Incidental diagnosis of a deep vein thrombosis in consecutive patients undergoing a computed tomography scan of the abdomen: a retrospective cohort study. J Thromb Haemost 2012;10: 158-60.
Ageno W, Dentali F, Squizzato A. How I treat splanchnic vein thrombosis. Blood. 2014;124: 3685-91.
Schulman S, Kearon C. Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on thrombosis and Haemostasis. Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. J Thromb Haemost 2005;3: 692-4.
Karam D, Iyer V, Agrawal B Occult myeloproliferative neoplasms: not so occult anymore. BMJ Case Rep 2017; 2017.
Northup PG, Caldwell SH. Coagulation in liver disease: a guide for the clinician. Clin Gastroenterol Hepatol 2013; 11: 1064-74.
Yates SG, Gavva C, Agrawal D, Sarode R. How do we transfuse blood components in cirrhotic patients undergoing gastrointestinal procedures? Transfusion 2016; 56: 791-8.
Tripodi A. Hemostasis abnormalities in cirrhosis. Curr Opin Hematol 2015; 22: 406-12
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