Correlation of Diffusion-weighted MR imaging and FDG PET/CT in the Diagnosis of Metastatic Lymph Nodes of Head and Neck Malignant Tumors

Şamil Şahin; Yaşar Kemal Duymaz; Burak Erkmen; Burak Karabulut; İldem Deveci; Mehmet Sürmeli; Aslı Şahin Yılmaz; Aslıhan Semiz Oysu; Çağatay Oysu

doi:10.58600/eurjther.20232902-450.y

Authors

Şamil Şahin Private Clinic, Istanbul, https://orcid.org/0000-0002-7378-6759
Yaşar Kemal Duymaz Department of Otolaryngology, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Turkey https://orcid.org/0000-0002-0215-0614
Burak Erkmen Department of Otolaryngology, University of Health Sciences, Sancaktepe Martyr Prof Dr Ilhan Varank Training and Research Hospital, İstanbul, Turkey https://orcid.org/0000-0002-9990-8099
Burak Karabulut Private Clinic, Istanbul, https://orcid.org/0000-0002-3958-3683
İldem Deveci Private Medient Hospital, Istanbul https://orcid.org/0000-0002-1573-8345
Mehmet Sürmeli Private Medient Hospital, Istanbul https://orcid.org/0000-0002-7936-2957
Aslı Şahin Yılmaz Department of Otolaryngology, University of Health Science, Lütfi Kırdar Training and Research Hospital, Istanbul, Turkey https://orcid.org/0000-0002-7846-9453
Aslıhan Semiz Oysu Department of Radiology, Marmara University, School of Medicine, Istanbul, Turkey https://orcid.org/0000-0001-6219-7097
Çağatay Oysu Department of Otolaryngology. Marmara University, Faculty of Medicine, Istanbul, Turkey https://orcid.org/0000-0002-6756-8456

DOI:

https://doi.org/10.58600/eurjther.20232902-450.y

Keywords:

Diffusion-weighted magnetic resonance imaging, head and neck cancer, squamous cell carcinoma, Fluoro-2-deoxy-d-glucose-Positron emission tomography

Abstract

Objectives: The aim of this study was to investigate the efficacy of DW-MRI as a reliable imaging modality for detecting metastatic neck lymph nodes of head and neck SCC.

Methods: 32 patients underwent FDG PET/CT and diffusion-weighted MRI were evaluated. Histopathologic analysis of lymph node metastases was used as the gold standard for assessment. We analyzed differences in sensitivity, specificity, accuracy, positive predictive value and negative predictive value among the imaging modalities using the Chi-square test. Their discriminative power evaluated using the Receiver-Operating Characteristic curve and calculation of the area under the curve. The correlation between ADCmin and SUVmax was calculated using the Spearman test. SPSS 24 was used for statistical analyses. P value of 0.05 indicates a statistically significant difference.

Results: A total of 32 patients with 50 neck dissections with head and neck SCC included. Sensitivity, specificity, accuracy, positive and negative predictive value of neck palpation was %72, %60, %70, %62 and %80 respectively. Sensitivity, specificity, accuracy, positive and negative predictive value of DW-MRI was %87,5, %96,2, %92, %95,5 and %89,3 respectively, according to ADCmin cutoff value 0.82×10-3s/mm2 . Sensitivity, specificity, accuracy, positive and negative predictive value of FDG-PET/CT was %91,7, %100, %96, %100 and %92,9 , respectively ,according to SUVmax cutoff value 3.4. For all neck dissections, there was a statistically significant inverse correlation between ADCmin and SUVmax (P<001).

Conclusion: DW-MRI is reliable as detecting cervical lymph node metastases as FDG-PET/CT. DWI and FDG PET/CT could play a complementary role in clinical assessment.

The original version of this article, unfortunately contained an error. The name of Aslıhan Semiz Oysu, who is one of the co-authors and took part in every stage of the study, was not inadvertently added to the author list by the corresponding author. The author apologizes for this confusion. Given in this article are the correct author names.

Correction to: https://doi.org/10.58600/eurjther1878

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