Apparent Diffusion Coefficient Values of Renal  Parenchyma in Healthy Adults: A 3 Tesla MRI Study

Hale Çolakoğlu Er

doi:10.5152/EurJTher.2019.18058

Authors

Hale Çolakoğlu Er Department of Radiology, Gaziantep University, School of Medicine, Gaziantep https://orcid.org/0000-0002-5210-734X

DOI:

https://doi.org/10.5152/EurJTher.2019.18058

Keywords:

Apparent diffusion coefficient, diffusion-weighted imaging, kidney

Abstract

Objective: In this study, we aimed to measure apparent diffusion coefficient (ADC) values of healthy renal parenchyma using diffusion-weighted imaging (DWI) in a 3 Tesla (3T) magnetic resonance imaging (MRI) device.
Methods: Apparent diffusion coefficient values of right and left renal parenchyma were measured in 87 individuals (64 females, 23 males) from DWIs obtained with a 3T MRI device. In the ADC measurement, bilateral renal parenchymal margins were drawn by the free-hand region of interest (ROI) on DWI (b=600 s/mm²), and ADCmean values were recorded from ROIs on the ADC map.
Results: The ADCmean value of renal parenchyma was 2.21x10−3 mm2/s and 2.2x10−3 mm2/s for the right and left kidney, respectively. Measured ADC values of the right and left renal parenchyma were highly consistent (Intraclass correlation coefficient (ICC=0.968; confidence interval (CI):[0.952–0.979]). ADC values of renal parenchyma were significantly lower in the group of patients older than or equal to 50 years as compared to the group of patients younger than 50 years (p=0.001). There was no significant difference between females and males in terms of the ADC values of renal parenchyma (p=0.161 for the right kidney, p=0.207 for the left kidney). Measured ADC values of the right and left renal parenchyma were highly consistent (ICC=0.968; CI:[0.952–0.979]). There was a strong negative correlation between ADC values of renal parenchyma and age (r=−0.686, p=0.001 for the right kidney; r=−0.759, p=0.001 for the left kidney).
Conclusion: Apparent diffusion coefficient values are quantitative values obtained by DWI, and it is important to understand the ADC values of normal healthy renal parenchyma in order to interpret ADC values in renal pathologies.

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References

Malayeri AA, El Khouli RH, Zaheer A, Jacobs MA, Corona-Villalobos CP, Kamel IR, et al. Principles and applications of diffusion-weighted imaging in cancer detection, staging, and treatment follow-up. Radiographics 2011; 31: 1773-91.

Baliyan V, Das CJ, Sharma R, Gupta AK. Diffusion weighted imaging: Technique and applications. World J Radiol 2016; 8: 785-98.

Li R, Wu G, Wang R. Application values of 3.0T magnetic resonance diffusion weighted imaging for distinguishing liver malignant tumors and benign lesions. Oncol Lett 2018; 15: 2091-6.

Fattahi R, Balci NC, Perman WH, Hsueh EC, Alkaade S, Havlioglu N, et al. Pancreatic diffusion-weighted imaging (DWI): comparison between mass-forming focal pancreatitis (FP), pancreatic cancer (PC), and normal pancreas. J Magn Reson Imaging 2009; 29: 350-6.

Zhang J, Tehrani YM, Wang L, Ishill NM, Schwartz LH, Hricak H. Renal masses: characterization with diffusion-weighted MR imaging--a preliminary experience. Radiology 2008; 247: 458-64.

Taouli B, Thakur RK, Mannelli L, Babb JS, Kim S, Hecht EM, et al. Renal lesions: characterization with diffusion-weighted imaging versus contrast-enhanced MR imaging. Radiology. 2009; 251: 398-407.

Çolakoğlu Er H, Peker E, Erden A, Öztürk E. The utility of diffusion-weighted imaging in differentiation of papillary and clear cell subtypes of renal cell carcinoma. Acta Oncol Turc 2015; 48: 8-14.

Manenti G, Di Roma M, Mancino S, Bartolucci DA, Palmieri G, Mastrangeli R, et al. Malignant renal neoplasms: correlation between ADC values and cellularity in diffusion weighted magnetic resonance imaging at 3 T. Radiol Med 2008; 113: 199-213.

Cova M, Squillaci E, Stacul F, Manenti G, Gava S, Simonetti G, et al. Diffusion-weighted MRI in the evaluation of renal lesions: preliminary results. Br J Radiol 2004; 77: 851-7.

Razek AA, Farouk A, Mousa A, Nabil N. Role of diffusion-weighted magnetic resonance imaging in characterization of renal tumors. J Comput Assist Tomogr 2011; 35: 332-6.

Abdel Razek AAK. Routine and Advanced Diffusion Imaging Modules of the Salivary Glands. Neuroimaging Clin N Am 2018; 28: 245-54.

Razek A, Al-Adlany M, Alhadidy AM, Atwa MA, Abdou NEA. Diffusion tensor imaging of the renal cortex in diabetic patients: correlation with urinary and serum biomarkers. Abdom Radiol (NY). 2017; 42: 1493-500.

Thoeny HC, Grenier N. Science to practice: Can diffusion-weighted MR imaging findings be used as biomarkers to monitor the progression of renal fibrosis? Radiology 2010; 255: 667-8.

Thoeny HC, De Keyzer F. Diffusion-weighted MR imaging of native and transplanted kidneys. Radiology 2011; 259: 25-38.

Damasio MB, Tagliafico A, Capaccio E, Cancelli C, Perrone N, Tomolillo C, et al. Diffusion-weighted MRI sequences (DW-MRI) of the kidney: normal findings, influence of hydration state and repeatability of results. Radiol Med 2008; 113: 214-24.

Xu Y, Wang X, Jiang X. Relationship between the renal apparent diffusion coefficient and glomerular filtration rate: preliminary experience. J Magn Reson Imaging 2007; 26: 678-81.

Muller MF, Prasad P, Siewert B, Nissenbaum MA, Raptopoulos V, Edelman RR. Abdominal diffusion mapping with use of a wholebody echo-planar system. Radiology 1994; 190: 475-8.

Yildirim E, Kirbas I, Teksam M, Karadeli E, Gullu H, Ozer I. Diffusion-weighted MR imaging of kidneys in renal artery stenosis. Eur J Radiol 2008; 65: 148-53.

Yildirim E, Gullu H, Caliskan M, Karadeli E, Kirbas I, Muderrisoglu H. The effect of hypertension on the apparent diffusion coefficient values of kidneys. Diagn Interv Radiol 2008; 14: 9-13.

Carbone SF, Gaggioli E, Ricci V, Mazzei F, Mazzei MA, Volterrani L. Diffusion-weighted magnetic resonance imaging in the evaluation of renal function: a preliminary study. Radiol Med 2007; 112: 1201-10.

Yoshikawa T, Kawamitsu H, Mitchell DG, Ohno Y, Ku Y, Seo Y, et al. ADC measurement of abdominal organs and lesions using parallel imaging technique. AJR Am J Roentgenol 2006; 187: 1521-30.

Muller MF, Prasad PV, Edelman RR. Can the IVIM model be used for renal perfusion imaging? Eur J Radiol 1998; 26: 297-303.Eur J Ther 2019; 25(1): 64-8 Çolakoğlu Er H. ADC Values of Renal Parenchyma in Healthy Adults 67

Kim T, Murakami T, Takahashi S, Hori M, Tsuda K, Nakamura H. Diffusion-weighted single-shot echoplanar MR imaging for liver disease. AJR Am J Roentgenol 1999; 173: 393-8.

Murtz P, Flacke S, Traber F, van den Brink JS, Gieseke J, Schild HH. Abdomen: diffusion-weighted MR imaging with pulse-triggered single-shot sequences. Radiology 2002; 224: 258-64.

Kilickesmez O, Yirik G, Bayramoglu S, Cimilli T, Aydin S. Non-breathhold high b-value diffusion-weighted MRI with parallel imaging technique: apparent diffusion coefficient determination in normal abdominal organs. Diagn Interv Radiol 2008; 14: 83-7.

Suo ST CM, Ding YZ, Yao QY, WU GY, Xu JR. Apparent diffusion coefficient measurements of bilateral kidneys at 3 T MRI: effects of age, gender, and laterality in healthy adults. Clin Radiol 2014; 69: 491-6.