Association of red Cell Distribution width with Characteristics of Coronary Atherosclerotic Plaques as Detected by Computed Tomography Angiography
Abstract views: 100
/ 
PDF downloads: 54
DOI:
https://doi.org/10.5152/EurJTher.2019.830Keywords:
Coronary atherosclerotic plaque, multidetector computed tomography angiography, red cell distribution widthAbstract
Objective: To evaluate the relationship between red blood cell distribution width (RDW) and the severity/morphology of coronary atherosclerotic plaques (CAPs).
Methods: We retrospectively analyzed 572 patients without a history of coronary artery disease (CAD) in whom dual-source 64-slice computed tomography angiography (CTA) was performed due to the suspicion of CAD.
Results: Critical CAPs were detected in 26.9% of subjects. The RDW value was higher in patients with critical CAPs than in those without (13.63±1.28 vs. 14.31±1.58, p<0.001). Patients with any type of CAP regardless of the morphology or severity revealed enhanced RDW levels compared with those with normal coronary arteries (p<0.001). In the multinomial logistic regression analysis, RDW was found as an independent predictor for the presence of severe CAP (odds ratio (OR): 1.40, 95% confidence interval (CI): 1.20–1.63, p<0.001). RDW was also found to be associated with the presence of non-calcified plaque (OR: 1.30, 95% CI: 1.08–1.57, p=0.006) and mixed plaque morphologies (OR: 1.47, 95% CI: 1.19–1.81, p<0.001) after adjusted for other variables.
Conclusion: Our findings suggested that RDW as a simple, available and inexpensive biomarker was significantly associated with both the severity and vulnerable morphology of CAPs in patients undergoing coronary CTA.
Metrics
References
Lin CK, Lin JS, Chen SY, Jiang ML, Chiu CF. Comparison of hemoglobin and red blood cell distribution width in the differential diagnosis of microcytic anemia. Arch Pathol Lab Med 1992; 116: 1030-2.
Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med 2005; 352: 1011-23.
Felker GM, Allen LA, Pocock SJ, Shaw LK, McMurray JJ, Pfeffer MA, et al. Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank. J Am Coll Cardiol 2007; 50: 40-7.
Anderson JL, Ronnow BS, Horne BD, Carlquist JF, May HT, Bair TL, et al. Usefulness of a complete blood count-derived risk score to predict incident mortality in patients with suspected cardiovascular disease. Am J Cardiol 2007; 99: 169-74.
Ma FL, Li S, Li XL, Liu J, Qing P, Guo YL, et al. Correlation of red cell distribution width with the severity of coronary artery disease: a large Chinese cohort study from a single center. Chin Med J 2013; 126: 1053-7.
Pundziute G, Schuijf JD, Jukema JW, Decramer I, Sarno G, Vanhoenacker PK, et al. Head-to-head comparison of coronary plaque evaluation between multislice computed tomography and intravascular ultrasound radiofrequency data analysis. JACC Cardiovasc Interv 2008; 1: 176-82.
Kantarcı M, Doğanay S, Karçaaltıncaba M, Karabulut N, Erol MK, Yalçın A, et al. Clinical situations in which coronary CT angiography confers superior diagnostic information compared with coronary angiography. Diagn Interv Radiol 2012; 18: 261-9.
Ozturk E, Kantarci M, Durur-Subasi I, Bayraktutan U, Karaman A, Bayram E, et al. How image quality can be improved: our experience with multidetector computed tomography coronary angiography. Clin Imaging 2007; 31: 11-7.
Tanboga IH, Aksakal E, Kurt M, Sagsoz ME, Kantarci M. Computed Tomography-Based SYNTAX Score: A Case Report. Eurasian J Med 2013; 45: 65-7.
Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, et al. Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 2003; 42: 1206-52.
Austen WG, Edwards JE, Frye RL, Gensini GG, Gott VL, Griffith LS, et al. A reporting system on patients evaluated for coronary artery disease. Report of the Ad Hoc Committee for Grading of Coronary Artery Disease, Council on Cardiovascular Surgery, American Heart Association. Circulation 1975; 51: 5-40.
Lippi G, Targher G, Montagnana M, Salvagno GL, Zoppini G, Guidi GC. Relation Between Red Blood Cell Distribution Width and Inflammatory Biomarkers in a Large Cohort of Unselected Outpatients. Arch Pathol Lab Med 2009; 133: 628-32.
Goncalves S, Santos JF, Amador P, Soares LN. Red blood cell distribution width: a prognostic marker of in-hospital death and bleeding events in patients with non-ST elevation acute coronary syndromes. Eur Heart J Suppl 2010; 12: 76-7.
Li X, Ren JY, Chen H. The relationship between red blood cell distribution width and early warning, risk stratification and short-term prognosis of acute coronary syndrome. Cardiology 2013; 126: 96-96.
Lippi G, Filippozzi L, Montagnana M, Salvagno GL, Franchini M, Guidi GC, et al. Clinical usefulness of measuring red blood cell distribution width on admission in patients with acute coronary syndromes. Clin Chem Lab Med 2009; 47: 353-7.
Tonelli M, Sacks F, Arnold M, Moye L, Davis B, Pfeffer M; for the Cholesterol and Recurrent Events (CARE) Trial Investigators. Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease. Circulation 2008; 117: 163-8.
Isik T, Uyarel H, Tanboga IH, Kurt M, Ekinci M, Kaya A, et al. Relation of red cell distribution width with the presence, severity, and complexity of coronary artery disease. Coron Artery Dis 2012; 23: 51-6.
Olivares Jara M, Santas Olmeda E, Miñana Escrivà G, Palau Sampio P, Merlos Díaz P, Sanchis Forés J, et al. Red cell distribution width and mortality risk in acute heart failure patients. Med Clin 2013; 140: 433-8.
Adamsson Eryd S, Borné Y, Melander O, Persson M, Smith JG, Hedblad B, et al. Red blood cell distribution width is associated with incidence of atrial fibrillation. J Intern Med 2014; 275: 84-92.
Demirkol S, Balta S, Celik T, Arslan Z, Unlu M, Cakar M, et al. Assessment of the relationship between red cell distribution width and cardiac syndrome X. Kardiol Pol 2013; 71: 480-4.
Drakopoulou M, Toutouzas K, Stefanadi E, Tsiamis E, Tousoulis D, Stefanadis C. Association of inflammatory markers with angiographic severity and extent of coronary artery disease. Atherosclerosis 2009; 206: 335-9.
Weiss G, Goodnough LT. Medical progress: Anemia of chronic disease. New Engl J Med 2005; 352: 1011-23.
Forhecz Z, Gombos T, Borgulya G, Pozsonyi Z, Prohaszka Z, Janoskuti L. Red cell distribution width in heart failure: Prediction of clinical events and relationship with markers of ineffective erythropoiesis, inflammation, renal function, and nutritional state. Am Heart J 2009; 158: 659-66.
Motoyama S, Kondo T, Sarai M, Sugiura A, Harigaya H, Sato T, et al. Multislice computed tomographic characteristics of coronary lesions in acute coronary syndromes. J Am Coll Cardiol 2007; 50: 319-26.
Pundziute G, Schuijf JD, Jukema JW, Decramer I, Sarno G, Vanhoenacker PK, et al. Evaluation of plaque characteristics in acute coronary syndromes: non-invasive assessment with multi-slice computed tomography and invasive evaluation with intravascular ultrasound radiofrequency data analysis. Eur Heart J 2008; 29: 2373-81.
Russo V, Zavalloni A, Bacchi Reggiani ML, Buttazzi K, Gostoli V, Bartolini S, et al. Incremental Prognostic Value of Coronary CT Angiography in Patients With Suspected Coronary Artery Disease. Circ Cardiovasc Imag 2010; 3: 351-9.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 European Journal of Therapeutics
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
The content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
