Effects of Voluntary and Forced Exercise on Anxiety-Related Behaviours and Motor Activity in Parkinson Mouse Model

Nadide Özkul Doğru; Ramazan Bal

doi:10.5152/EurJTher.2018.18011

Authors

Nadide Özkul Doğru Department of Physiology, Gaziantep University School of Medicine, Gaziantep https://orcid.org/0000-0003-2027-0748
Ramazan Bal Department of Physiology, Gaziantep University School of Medicine, Gaziantep https://orcid.org/0000-0003-3829-8669

DOI:

https://doi.org/10.5152/EurJTher.2018.18011

Keywords:

Anxiety, forced exercise, motor activity, Parkinson’s disease, voluntary exercise

Abstract

Objective: The aim of this study was to investigate the effect of two different types of exercise, voluntary and forced, on motor activity and anxiety in a neurotoxic parkinsonian mouse model.
Methods: Parkinsonian mice exposed to neurotoxin underwent voluntary exercise (VE) and moderate forced exercise (FE). The motor activity levels were then measured using the rotarod and pole test. Anxiety was assessed using an open-field test (OFT) and elevated plus maze (EPM) test.
Results: Bradykinesia, a motor dysfunction, was assessed using the pole test. The Tturn and Ttotal durations were significantly reduced in Parkinson-induced FE (p<0.001). The motor activity was assessed with the rotarod test, and the best improvement was in the long-term FE group (p<0.001). The time spent on the opened arms in the EPM test or the time spent in the peripheral zone in the OFT is significantly shorter in the Parkinson groups that performed FE than the VE groups. This suggests that the FE group is more anxious.
Conclusion: The study showed that long-term FE was the best exercise to improve the motor function. Moderate-intensity FE provided restorative effects on the motor symptoms of the disease. However, while this type of exercise increases anxiety, the VE has a healing effect on anxiety. Data obtained in this study showed that exercise provided an effective improvement in motor skills and anxiety behaviors. Thus, exercise is an effective and non-invasive way to be safely recommended by clinicians to all patients with Parkinson’s disease.

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