Comparison of Pineal Gland Volume Between Patients with Fibromyalgia and Healthy Controls Running Title: Pgv in Fibromyalgia

Çağlar Karabaş; Samet Karahan; Havva Talay Çalış; Ali Koç

doi:10.58600/eurjther-28-4-0104

Authors

Çağlar Karabaş Kastamonu Physical Therapy and Rehabilitation Center, Department of Physical Medicine and Rehabilitation, Kastamonu, Turkey https://orcid.org/0000-0003-4141-7972
Samet Karahan Kayseri City Hospital, Department of Internal Medicine Division of Rheumatology, Kayseri, Turkey https://orcid.org/0000-0003-2065-4047
Havva Talay Çalış Kayseri City Hospital, Department of Physical Medicine and Rehabilitation, Kayseri, Turkey https://orcid.org/0000-0002-8897-8921
Ali Koç Kayseri City Hospital, Department of Radiology, Kayseri, Turkey https://orcid.org/0000-0003-0296-4914

DOI:

https://doi.org/10.58600/eurjther-28-4-0104

Keywords:

Fibromyalgia syndrome, pineal gland volume, functional pineal gland volume, pineal gland magnetic resonance imaging

Abstract

Objectives: The pineal gland is an important neuroendocrine organ accounting for the melatonin secretion and chronobiology that regulate circadian rhythm. This study was designed to compare pineal gland volume (PGV) with healthy controls and patients with fibromyalgia syndrome (FM), in which sleep quality and efficiency is reduced. Patient and

Methods: In this cross-sectional study, PGV and functional pineal gland volume (FPGV) of FM patients with age- and sex-matched healthy controls were compared. All MR imaging studies were performed using a 3 Tesla scanner with a multi-channel phased array head coil. The volume of pineal glands and pineal cysts were calculated from 3D MP RAGE images using the formula: volume= AP x transverse x craniocaudal diameter x 0.523.

Results: There was no significant difference in PGV and FPGV between the FM group and healthy controls (p=0.374 and p=0.421, respectively). In the correlation analysis, age was negatively correlated with PGV and FPGV in the FM group (r=-0.496, p=0.010; r=- 0.477, p=0.014, respectively). No significant correlation was detected between age, PGV and FPGV in the control group (r= 0.022, p=0.916; r= -0.019, p=0.925, respectively).

Conclusions: Based on the results, there was no significant difference between the FM group and healthy controls regarding PGV and FPGV. However, PGV and FPGV were decreased by advancing age in the FM group in which melatonin therapy is offered as an option.

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