Serum Adropin Level in Patients with Isolated Coronary Artery Ectasia

Mehmet Küçükosmanoğlu; Mehmet Kaplan; Fethi Yavuz

doi:10.5152/eurjther.2020.19119

Authors

Mehmet Küçükosmanoğlu University of Health Sciences, Adana Health Practice and Research Center, Adana https://orcid.org/0000-0001-9186-3642
Mehmet Kaplan University of Health Sciences, Adana Health Practice and Research Center, Adana https://orcid.org/0000-0001-7081-5799
Fethi Yavuz University of Health Sciences, Adana Health Practice and Research Center, Adana https://orcid.org/0000-0003-1913-4212

DOI:

https://doi.org/10.5152/eurjther.2020.19119

Keywords:

Adropin, coronary ectasia, endothelial dysfunction

Abstract

Objective: Isolated coronary artery ectasia (iCAE) is characterized by localized or diffuse dilatation of the coronary arteries, and the exact mechanism underlying iCAE is unclear. However, endothelial dysfunction is related to iCAE. Adropin has a regulatory effect in the coronary artery endothelium. This study aimed to determine the relationship of adropin level to iCAE.
Methods: Fifty patients with iCAE and 32 age- and sex-matched control subjects with normal coronary angiography (CAG) findings were selected from 4546 patients who underwent CAG between July 2019 and October 2019. Blood sample for adropin analysis were collected just before CAG.
Results: No significant difference was found between groups in terms of baseline characteristics and laboratory parameters. The mean adropin level in patients with iCAE was significantly lower than that in control subjects (0.33±0.35 vs. 0.55±0.35 ng/mL, (p<0.001). In receiver operating characteristic analysis, the cut-off value of adropin ≤0.341 had 76.0% sensitivity and 84.37% specificity for predicting iCAE (area under the curve: 0.839, p<0.001). Multivariate analysis included age, left ventricular ejection fraction,and adropin level, which showed that adropin (per 1 ng/dL decrease) (odds ratio: 0.973 [0.956–0.990]; p=0.002) was independently associated with iCAE.
Conclusion: The present study showed that adropin level is significantly lower in patients with iCAE patients and is independently associated with iCAE.

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References

Çekici Y, Kılıç S, Saraçoğlu E, Çetin M, Veysel Düzen İ, Yılmaz M. The Relationship between Blood Viscosity and Isolated Coronary Artery Ectasia. Acta Cardiol Sin 2019; 35: 20-6.

Erdoğan T, Kocaman SA, Çetin M, Durakoğlugil ME, Kırbaş A, Canga A, et al. Increased YKL-40 levels in patients with isolated coronary artery ectasia: an observational study. Anadolu Kardiyol Derg 2013; 13: 465-70.

Kundi H, Gok M, Kiziltunc E, Cetin M, Cicekcioglu H, Guven Cetin Z, et al. "Relation between monocyte to high-density lipoprotein cholesterol ratio with presence and severity of isolated coronary artery ectasia". Am J Cardiol 2015; 116: 1685-9.

Balin M, Celik A, Kobat MA. The association between soluble lectin-like oxidized low-density lipoprotein receptor-1 levels and patients with isolated coronary artery ectasia. J Thromb Thrombolysis 2012; 33: 239-45.

Antonopoulos AS, Siasos G, Oikonomou E, Mourouzis K, Mavroudeas SE, Papageorgiou N, et al. Characterization of vascular phenotype in patients with coronary artery ectasia: the role of endothelial dysfunction. Int J Cardiol 2016; 215: 138-9.

Lovren F, Pan Y, Quan A, Singh KK, Shukla PC, Gupta M, et al. Adropin is a novel regulator of endothelial function. Circulation 2010; 122: S185-92.

Devabhaktuni S, Mercedes A, Diep J, Ahsan C. Coronary artery ectasia-a review of current literature. Curr Cardiol Rev 2016; 12: 318-23.

Liu R, Chen L, Wu W, Chen H, Zhang S. "Extracellular matrix turnover in coronary artery ectasia patients". Heart Vessels 2016; 31: 351-9.

Antoniadis AP, Chatzizisis YS, Giannoglou GD. Pathogenetic mechanisms of coronary ectasia. Int J Cardiol 2008; 130: 335-43.

Markis JE, Joffe CD, Cohn PF, Feen DJ, Herman MV, Gorlin R. Clinical significance of coronary arterial ectasia. Am J Cardiol 1976; 37: 217-22.

Doğduş M, Güler TE. İzole koroner arter ektazili hastalarda aterojenik dislipideminin araştırılması. Kocaeli Tıp Dergisi 2019; 8: 173-81.

Bilik MZ, Kaplan İ, Yıldız A, Akıl MA, Acet H, Yüksel M, et al. Apelin levels In Isolated coronary artery ectasia. Korean Circ J 2015; 45: 386-90.

Triantafyllis AS, Kalogeropoulos AS, Rigopoulos AG, Sakadakis EA,Toumpoulis IK, Tsikrikas S, et al. Coronary artery ectasia and inflammatory cytokines: link with a predominant Th-2 immune response? Cytokine 2013; 64: 427-32.

Eid MD, Abdelaziz AA, Hassan NA. "Isolated coronary artery ectasia debate: Inflammation versus atherosclerosis." The Egyptian Heart Journal 2012; 64: 185-90.

Li JJ. "Inflammation in coronary artery diseases." Chin Med J 2011;124: 3568-75.

Kocaman SA, Taçoy G, Sahinarslan A, Cengel A. Relationship between total and differential leukocyte counts and isolated coronaryartery ectasia. Coron Artery Dis 2008; 19: 307-10.

Levine AB, Punihaole D, Levine TB. "Characterization of the role of nitric oxide and its clinical applications." Cardiology 2012; 122: 55-68.

Tousoulis D, Kampoli AM, Tentolouris C, Papageorgiou N, Stefanadis C. The role of nitric oxide on endothelial function. Curr Vasc Pharmacol 2012; 10: 4-18.

Giles TD, Sander GE, Nossaman BD, Kadowitz PJ. Impaired vasodilation in the pathogenesis of hypertension: focus on nitric oxide, endothelial‐derived hyperpolarizing factors, and prostaglandins. J Clin Hypertens 2012; 14: 198-205.

Park, KH, Park WJ. Endothelial dysfunction: clinical implications in cardiovascular disease and therapeutic approaches. J Korean Med Sci 2015; 30: 1213-25.

Gürlek A, Esenboğa K, Özcan ÖU, Çiçek ÖF, Arıbal Ayral P, Özelçi Kavas G, et al. Serum nitric oxide levels in patients with coronary artery ectasia. Anatol J Cardiol 2016; 16: 947-52.

Petersen TN, Brunak S, von Heijne G, Nielsen H. SignalP 4.0: discriminating signal peptides from transmembrane regions. Nat Methods2011; 8: 785-6.

Zhao ZW, Ren YG, Liu J. Low serum adropin levels are associated with coronary slow flow phenomenon. Acta Cardiol Sin 2018; 34:307-12.

Oruc CU, Akpinar YE, Dervisoglu E, Amikishiyev S, Salmaslıoglu A,Gurdol F, et al. Low concentrations of adropin are associated withendothelial dysfunction as assessed by flow-mediated dilatation in patients with metabolic syndrome. Clin Chem Lab Med 2017; 55:139-44.

Wu L, Fang J, Chen L, Zhao Z, Luo Y, Lin C et al. Low serum adropin is associated with coronary atherosclerosis in type 2 diabetic and non-diabetic patients. Clin Chem Lab Med 2014; 52: 751-58.

Yu HY, Zhao P, Wu MC, Liu J, Yin W. Serum adropin levels are decreased in patients with acute myocardial infarction. Regul Pept2014; 190: 46-9.

Demircelik B, Cakmak M, Nazli Y, Gurel OM, Akkaya N, Cetin M, et al. Adropin: a new marker for predicting late saphenous vein graft disease after coronary artery bypass grafting. Clin Invest Med 2014: E338-44.