The Relationship between Mitral Chordae Rupture  and Inflammation Level and Oxidative Stress

Mehmet Kaplan; Fethi Yavuz; Vedat Davutoğlu; Murat Yüce; Yurdaer Dönmez; Özge Özcan Abacıoğlu

doi:10.5152/eurjther.2019.19063

Authors

Mehmet Kaplan Science and Health University, Adana City Training & Research Hospital, Adana
Fethi Yavuz Science and Health University, Adana City Training & Research Hospital, Adana
Vedat Davutoğlu Department of Cardiology, Gaziantep University School of Medicine, Gaziantep
Murat Yüce Department of Cardiology, Gaziantep University School of Medicine, Gaziantep
Yurdaer Dönmez Science and Health University, Adana City Training & Research Hospital, Adana
Özge Özcan Abacıoğlu Science and Health University, Adana City Training & Research Hospital, Adana

DOI:

https://doi.org/10.5152/eurjther.2019.19063

Keywords:

Chordae rupture, IL-6, Mitral valve, oxidative stress, TNFα

Abstract

Objective: Several factors have been reported to be associated with chordae tendineae rupture. The present study aimed at investigating the role of Interleukin-6 (IL-6), total antioxidant activity (TAA), total oxidant activity (TOA), and tumor necrosis factor alpha (TNFα) levels in the development of the mitral valve chordae tendinea rupture.
Methods: In this comparative study, 30 patients with mitral chordae rupture, 30 with severe rheumatic mitral regurgitation, and 20 healthy participants who were admitted to the Gaziantep University Medicine Faculty Cardiology Polyclinic were included. None of the participants had a previously known comorbid disease, and their diagnoses were confirmed by transthoracic echocardiography, followed by transesophageal echocardiography. Plasma levels of IL-6, TAA–TOA, and TNFα in all patients were measured and their oxidative stress index (OSI) was calculated.
Results: While the TOA–OSI levels in the chordae rupture group were significantly higher than the levels in patients with severe rheumatic mitral insufficiency and the control group (p=0.038 and p=0.019, respectively), the TNFα levels in the severe rheumatic mitral insufficiency group were statistically and significantly higher than the chordae rupture group (p=0.028).
Conclusion: Our study reports for the first time the significant relationship between the chordae rupture and oxidative stress levels (TOA-OSI). The results of this study show that high oxidative stress can be accepted as a risk factor for chordae rupture. In addition, it has also been observed that the TNFα level in the severe rheumatic mitral insufficiency group was higher than in the chordae rupture group. These data support the role of inflammation in the development of severe rheumatic mitral insufficiency.

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