Serum Nuclear Factor Erythroid-2 Related Factor-2 (NRF2) as an Indicator of Oxidative  Stress is Related to Coronary in-Stent Restenosis

Ferhat Coskun; Ertan Vuruskan; Irfan Veysel Duzen; Mehmet Kaplan; Gokhan Altunbas; Mehmet Akif Bozdayi; Tanyeli Guneyligil Kazaz; Seyithan  Taysi; Murat Sucu

doi:10.58600/eurjther.20232902-35.y

Authors

Ferhat Coskun Department of Cardiology, Faculty of Medicine, Gaziantep University, Turkey https://orcid.org/0000-0002-8298-1978
Ertan Vuruskan Department of Cardiology, Faculty of Medicine, Gaziantep University, Turkey https://orcid.org/0000-0001-6820-3582
Irfan Veysel Duzen Department of Cardiology, Faculty of Medicine, Gaziantep University, Turkey https://orcid.org/0000-0003-2312-4252
Mehmet Kaplan Department of Cardiology, Faculty of Medicine, Gaziantep University, Turkey https://orcid.org/0000-0001-7081-5799
Gokhan Altunbas Department of Cardiology, Faculty of Medicine, Gaziantep University, Turkey https://orcid.org/0000-0002-0171-0464
Mehmet Akif Bozdayi Department of Biochemistry, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey https://orcid.org/0000-0003-0459-0629
Tanyeli Guneyligil Kazaz Department of Biostatistics, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey https://orcid.org/0000-0002-4191-1244
Seyithan Taysi Department of Biochemistry, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey https://orcid.org/0000-0003-1251-3148
Murat Sucu Department of Cardiology, Faculty of Medicine, Gaziantep University, Turkey https://orcid.org/0000-0002-3695-5461

DOI:

https://doi.org/10.58600/eurjther.20232902-35.y

Keywords:

NRF2, Thiol/Disulfate, Neointimal Hyperplasia, In-Stent Restenosis

Abstract

Objective: In the treatment of coronary artery disease, stent implantation has become the standard treatment, but development of in-stent restenosis (ISR) limits the benefit of this treatment modality.

Methods: Based on the connection between oxidative stress and thiol/disulphate and NRF2, it was intended to measure NRF2 and thiol/disulphate levels.

Results: Coronary angiography images of 76 stable angina pectoris patients were evaluated. Of the 51 patients with a history drug eluting stent implantation, we determined 25 patients with ISR (Group 1) and 26 patients without ISR (Group 2). Twenty-five patients with normal coronary arteries were included in the study as control group (Group 3). NRF2 level was found to be significantly higher in patients who did not develop ISR (p=0.01). Total thiol was significantly higher in group 3 (738.76 micromole/L) compared to group 1 (626.11 micromole/L) and group 2 (630.27 micromole/L) (p=0.014). Native thiol was also significantly higher in group 3 (570.53 micromole/L) compared to group 1 (483.91 micromole/L) and group 2 (501 micromole/L) (p=0.006).

Conclusion: We think that total and native thiol levels might be useful as an indicator of oxidative stress in early diagnosis of coronary artery disease, and the NRF2 level can be used in predicting patients who might develop coronary ISR.

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