Systemic Immune Inflammation-Index and CANLPH Score in Patients with Mitral Stenosis Undergoing Balloon Valvuloplasty

Ozge Ozcan Abacioglu; Arafat Yıldırım; Mine Karadeniz; Armagan Acele; Ferhat Dindas; Nemin Yıldız Koyunsever; Mustafa Dogdus; İbrahim Halil Kurt

doi:10.58600/eurjther-339

Authors

Ozge Ozcan Abacioglu Adana City Training and Research Hospital, Department of Cardiology, Adana https://orcid.org/0000-0003-1392-9380
Arafat Yıldırım Adana City Training and Research Hospital, Department of Cardiology, Adana https://orcid.org/0000-0002-2798-7488
Mine Karadeniz Hacettepe University, Department of Hematology, Ankara https://orcid.org/0000-0002-2502-2594
Armagan Acele Adana City Training and Research Hospital, Department of Cardiology, Adana https://orcid.org/0000-0002-8535-7855
Ferhat Dindas Usak University Faculty of Medicine, Department of Cardiology, Usak https://orcid.org/0000-0003-0053-9594
Nemin Yıldız Koyunsever Adana City Training and Research Hospital, Department of Cardiology, Adana https://orcid.org/0000-0002-0058-1330
Mustafa Dogdus Usak University Faculty of Medicine, Department of Cardiology, Usak https://orcid.org/0000-0002-3895-1923
İbrahim Halil Kurt Adana City Training and Research Hospital, Department of Cardiology, Adana https://orcid.org/0000-0001-5007-2246

DOI:

https://doi.org/10.58600/eurjther-339

Keywords:

CANLPH score, mitral stenosis, percutaneous balloon valvuloplasty, systemic immune-inflammation index

Abstract

Objective: to evaluate CANLPH score and systemic immune inflammation index (SII) in patients with symptomatic rheumatic mitral stenosis (MS) undergoing percutaneous mitral balloon valvuloplasty (PMBV).

Methods: 62 patients who underwent PMBV in our clinic between 2018 and 2021 were included retrospectively. The patients were divided into 2 groups according to echo score. The CANLPH score was calculated from the cut-off values of C-reactive protein to albumin ratio (CAR), neutrophil to lymphocyte ratio (NLR) and platelet to hemoglobin ratio (PHR), determined with the Youden index and SII by the formula platelet x neutrophil/lymphocyte. P <0.05 was considered statistically significant.

Results: The mean age of the patients was 44.5±10.4 years (40 female, 64.5%). The mean values of SII and CANLPH scores were higher in the Echo score >8 group (p <0.001, both). The mean mitral gradient before and after PMBV was 12.6±5.7mm Hg and 5.0±2.4 mm Hg, and the mean valve area was 1.12±0.27 cm2 and 1.85±0.29 cm2. A statistically significant and negative correlation was observed between the gradient decrease after the procedure and the CANLPH score and SII (r=-0.426, p=0.001 and r=-0.418, p=0.001, respectively). In receiver operating characteristic (ROC) curve analysis, it was concluded that the ability of CANPLH score to predict the higher Echo scores was noninferior to SII with an area under curve (AUC:0.820 (0.701-0.906) and AUC:0.786 (0.664-0.880), z statistics 0.576 and p=0.564.

Conclusion: SII and CANLPH scores are correlated with Echo score. A significant negative relationship was found with both biomarkers and gradient decrease after the PMBV.

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