The Effect of Sedative Agents on Stress Hormones  and High-Sensitive Troponin in Patients  Catheterized by Permanent-tunnel Port Catheter: Kalıcı Tünelli Port Kateter Takılan Hastalarda Sedatif Ajanların  Stress Hormonları ve High Sensitif Troponin Üzerine Etkileri

Yılmaz Safi; Cuma Yıldırım; Cem Şen; Mustafa Sabak; Süleyman Nogay; Seyithan Taysi; Hasan Ulusal; Suat Zengin

doi:10.5152/eurjther.2017.172

Authors

Yılmaz Safi Department of Emergency Medicine, Gaziantep University School of Medicine, Gaziantep
Cuma Yıldırım Department of Emergency Medicine, Gaziantep University School of Medicine, Gaziantep https://orcid.org/0000-0002-3504-8771
Cem Şen Department of Emergency Medicine, Gaziantep University School of Medicine, Gaziantep
Mustafa Sabak Department of Emergency Medicine, Gaziantep University School of Medicine, Gaziantep
Süleyman Nogay Department of Emergency Medicine, Gaziantep University School of Medicine, Gaziantep
Seyithan Taysi Department of Biochemistry, Gaziantep University School of Medicine, Gaziantep
Hasan Ulusal Department of Biochemistry, Gaziantep University School of Medicine, Gaziantep
Suat Zengin Department of Emergency Medicine, Gaziantep University School of Medicine, Gaziantep

DOI:

https://doi.org/10.5152/eurjther.2017.172

Keywords:

Port catheter, sedation, anxiety, troponin

Abstract

Objective: To evaluate the effects of sedation and analgesia combinations on pain scales, anxiety, adrenocorticotropic hormone (ACTH), cortisol, and high-sensitive troponin in patients with a central venous catheter.
Methods: The present study was prospectively conducted in 90 patients who had been indicated for port catheterization in hematology and oncology in the emergency medicine department of Gaziantep University Medical Faculty between March 1st and September 1st, 2015. The patients were divided into three groups of 30 each. Pain levels were assessed using the Visual Analog Scale, anxiety levels using the Beck Anxiety Scale, and blood samples were collected before (0 min) and after (30 min) the procedure in order to obtain ACTH, cortisol, and high-sensitive troponin values.
Results: No statistically significant differences were observed between the groups with regard to gender and age (p=0.836 and p=0.182, respectively). Anxiety significantly decreased in all three groups. A significant decrease in level of pain was found in patients administering midazolam-fentanyl and those who received propofol; a significant decrease in systolic and diastolic blood pressure was also observed in these two groups. In all three groups, no significant cortisol change was found; however, significant high-sensitive troponin values were observed. There was no significant difference between the groups.
Conclusion: Sedative agents can be used efficiently, safely, and easily in minor surgical procedures, such as central venous catheterization. We also recommend the use of analgesic drugs, in addition to anxiolytic and sedative agents, during invasive procedures conducted in the emergency room.

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