The Efficacy of Haematologic Parameters in the Diagnosis of Missed Abortus
Hematolojik Parametrelerin Missed Abortus Tanısına Etkileri
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Keywords:Cancer antigen 125, hematologic parameters, missed abortus, red cell distribution width
Objective: The aim of the present study was to investigate the efficacy of hematologic parameters in diagnosing missed abortus (MA). Our second aim was to elucidate the diagnostic value of maternal serum cancer antigen 125 (CA 125) levels in missed abortion.
Methods: Hemoglobin, white blood cell, neutrophil, lymphocyte, and platelet levels; mean corpuscular volume; mean platelet volume (MPV); and red cell distribution width (RDW) in complete blood count samples were obtained from all patients diagnosed with MA (group 1; n=90) and from women with healthy pregnancies (group 2; n=143).
Results: Lymphocyte, platelet, and RDW variables were significantly higher in group 1 (p=0.03, p=0.003, and p=0.005, respectively). High RDW value was independent predictors of MA (OR: 0.810, p<0.05). Mean CA 125 levels between the groups were similar. There was no significant difference in other hematologic laboratory parameters between the groups.
Conclusion: Of all hematologic inflammatory markers, higher RDW value was the only marker associated with MA. RDW might be used as an early promising predictor of MA with low cost. Second, we found that CA 125 and other hematologic inflammatory markers, such as MPV and neutrophil/lymphocyte ratio, are not good markers for predicting MA.
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