Effect of Helicobacter Pylori Infection on  Duodenitis in Patients with Dyspepsia: Dispepsisi Olan Hastalarda Helicobacter pylori Enfeksiyonunun Duodenit Üzerine Etkisi

Buğra Tolga Konduk; Şeniz Demiryürek; Abdullah Emre Yıldırım; Sezgin Barutçu; Ramazan Erdem Er; Ayhan Balkan; Yeşim Gürbüz; Ömer Şentürk

doi:10.5152/eurjther.2017.262

Authors

Buğra Tolga Konduk Department of Gastroenterology, Gaziantep University School of Medicine, Gaziantep https://orcid.org/0000-0002-9138-9984
Şeniz Demiryürek Department of Physiology, Gaziantep University School of Medicine, Gaziantep https://orcid.org/0000-0003-4762-4745
Abdullah Emre Yıldırım Department of Gastroenterology, Gaziantep University School of Medicine, Gaziantep https://orcid.org/0000-0002-4386-9297
Sezgin Barutçu Department of Gastroenterology, Gaziantep University School of Medicine, Gaziantep https://orcid.org/0000-0003-0823-3215
Ramazan Erdem Er Department of Gastroenterology, Gaziantep University School of Medicine, Gaziantep https://orcid.org/0000-0002-9708-1163
Ayhan Balkan Department of Gastroenterology, Gaziantep University School of Medicine, Gaziantep https://orcid.org/0000-0002-6475-9847
Yeşim Gürbüz Department of Pathology, Kocaeli University School of Medicine, Kocaeli https://orcid.org/0000-0002-4278-8241
Ömer Şentürk Department of Gastroenterology, Kocaeli University School of Medicine, Kocaeli https://orcid.org/0000-0003-2342-9136

DOI:

https://doi.org/10.5152/eurjther.2017.262

Keywords:

Duodenitis, Helicobacter pylori, dyspepsia, endoscopy, histopathology

Abstract

Objective: Helicobacter pylori (H. pylori) infection is one of the principal causes of many gastroduodenal diseases, but its role in duodenitis development is not exactly known. The purpose of this study was to elucidate the role of gastric H. pylori infection on clinical, laboratory, and endoscopical features of duodenitis in patients with dyspepsia.
Methods: A total number of 131 patients (77 females and 54 males) were enrolled in the study. The control group was formed from H. pylori-negative dyspepsia patients (n=60). Clinical, biochemical, and endoscopical evaluations were performed on all subjects. Biopsies were obtained from the gastric antrum, corpus, and duodenal bulb to detect H. pylori and for histopathological assessments.
Results: H. pylori infection was positive in 71 patients (54.2%). We detected ulcer-like dyspepsia in 87 patients (66.4%) and dysmotility-like dyspepsia in 44 patients (33.6%). There were no marked differences in biochemical parameters between the groups. On the other hand, there was a marked decrease in ferritin levels in H. pylori-positive group (p=0.001). Endoscopical examination showed that the H. pylori-positive group had more frequent erosive duodenitis (p=0.039). Villous obliteration and duodenal intraepithelial lymphocytosis as histopathological features were seen more commonly in the H. pylori-positive group (p<0.001 for both).
Conclusion: Our data demonsrated that the presence of gastric H. pylori infection is one of the components that can influence the endoscopical, histopathological and laboratory features of duodenitis.

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