Effect of Helicobacter Pylori Infection on Duodenitis in Patients with Dyspepsia
Dispepsisi Olan Hastalarda Helicobacter pylori Enfeksiyonunun Duodenit Üzerine Etkisi
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Keywords:Duodenitis, Helicobacter pylori, dyspepsia, endoscopy, histopathology
Objective: Helicobacter pylori (H. pylori) infection is one of the principal causes of many gastroduodenal diseases, but its role in duodenitis development is not exactly known. The purpose of this study was to elucidate the role of gastric H. pylori infection on clinical, laboratory, and endoscopical features of duodenitis in patients with dyspepsia.
Methods: A total number of 131 patients (77 females and 54 males) were enrolled in the study. The control group was formed from H. pylori-negative dyspepsia patients (n=60). Clinical, biochemical, and endoscopical evaluations were performed on all subjects. Biopsies were obtained from the gastric antrum, corpus, and duodenal bulb to detect H. pylori and for histopathological assessments.
Results: H. pylori infection was positive in 71 patients (54.2%). We detected ulcer-like dyspepsia in 87 patients (66.4%) and dysmotility-like dyspepsia in 44 patients (33.6%). There were no marked differences in biochemical parameters between the groups. On the other hand, there was a marked decrease in ferritin levels in H. pylori-positive group (p=0.001). Endoscopical examination showed that the H. pylori-positive group had more frequent erosive duodenitis (p=0.039). Villous obliteration and duodenal intraepithelial lymphocytosis as histopathological features were seen more commonly in the H. pylori-positive group (p<0.001 for both).
Conclusion: Our data demonsrated that the presence of gastric H. pylori infection is one of the components that can influence the endoscopical, histopathological and laboratory features of duodenitis.
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