Effect of Peri-Implant Disease on Adropin Levels:  A Cross-Sectional Pilot Study

Hasan Gündoğar; Buket Özsoy; Meral Uzunkaya; Süleyman Ziya Şenyurt; Kamile Erciyas

doi:10.5152/eurjther.2020.19107

Authors

Hasan Gündoğar Department of Peridontology, Gaziantep University School of Medicine, Gaziantep https://orcid.org/0000-0003-3853-2689
Buket Özsoy Clinic of Peridontology, Ministry of Heathy Hospital, Gaziantep https://orcid.org/0000-0001-6582-9299
Meral Uzunkaya Clinic of Peridontology, Ministry of Heathy Hospital, Gaziantep https://orcid.org/0000-0001-7605-6527
Süleyman Ziya Şenyurt Department of Peridontology, Gaziantep University School of Medicine, Gaziantep https://orcid.org/0000-0001-5536-9110
Kamile Erciyas Department of Peridontology, Gaziantep University School of Medicine, Gaziantep https://orcid.org/0000-0001-9940-0423

DOI:

https://doi.org/10.5152/eurjther.2020.19107

Keywords:

Adropin, periodontal disease, peri-implant disease

Abstract

Objective: Adropin is a peptide hormone related to the inflammatory process of several systemic diseases. The inflammatory characteristics of peri-implant diseases are known. This study aimed to measure and compare the level of adropin in peri-implant sulcus fluid (PISF) in patients with peri-implant disease.
Methods: Overall, 75 individuals were included in this cross-sectional study. Each of the three study groups [healthy (H), peri-implant mucositis (PM), and peri-implantitis (PI)] consisted of 25 patients. During the periodontal examination, periodontal pocket depth (PD), plaque index (PI), and gingival index (GI) scores were recorded, and marginal bone loss (MBL) was measured using ImageJ. PISF samples were collected from dental implants. Adropin level in PISF was analyzed using the enzyme-linked immunosorbent assay (ELISA) technique. All clinical and biochemical parameters were statistically analyzed using SPSS v22.
Results: PD, PI, and GI parameters were noted to be significantly higher in the PM and PI groups compared with the H group. PI group showed statistically significant differences related to MBL compared with the other groups (p<0.05).
Conclusion: Therefore, adropin may prove to be a useful diagnostic tool in the diagnosis of peri-implant disease. However, further studies are needed to explore the different biochemical parameters in PISF, thereby helping to understand the interaction of adropin with other mediators.

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