Malignant Transformation of Mature Cystic  Teratomas: A Retrospective Analysis of 181 Cases

Zehra Bozdağ; Neslihan Bayramoğlu Tepe

doi:10.5152/eurjther.2020.19108

Authors

Zehra Bozdağ Department of Pathology, Gaziantep University School of Medicine, Gaziantep https://orcid.org/0000-0002-0477-2513
Neslihan Bayramoğlu Tepe Department of Obstetrics and Gynecology, Gaziantep University School of Medicine, Gaziantep https://orcid.org/0000-0003-0396-5791

DOI:

https://doi.org/10.5152/eurjther.2020.19108

Keywords:

Malignancy, mature cystic teratoma, ovarian tumor

Abstract

Objective: Mature cystic teratoma (MCT) constitutes 20% of all ovarian tumors and is the most prevalent ovarian germ cell tumor. Notably, any of its component tissues may undergo a malignant transformation (MT). This study aimed to retrospectively analyze the malignancies that arise from MCT of the ovary.
Methods: Data of histopathological analysis of ovarian masses resected from adult patients and diagnosed at our laboratory between January 2012 and December 2018 were reviewed.
Results: Of our 181 cases, 7 (3.86%) were detected to have MT. Among the MT cases, five had papillary thyroid carcinoma, one had squamous cell carcinoma, and one had a strumal carcinoid.
Conclusion: The diagnosis of malignancies arising from MCT is crucial to decide on the follow-up and treatment options for patients. Reporting data obtained from cases that demonstrate MT will aid in the pre-and postoperative management of patients.

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