The Predictive Role of Heat Shock Proteins 27 and 60 in Pediatric Patients with Ataxia Telangiectasia

Aysima Özçelik; Peren Perk; Binnur Özyurt; Beltinge Demircioğlu Kılıç

doi:10.5152/eurjther.2020.20019

Authors

Aysima Özçelik Division of Pediatric Neurology, Gaziantep University School of Medicine, Gaziantep https://orcid.org/0000-0002-0713-7654
Peren Perk Division of Pediatric Neurology, Gaziantep University School of Medicine, Gaziantep
Binnur Özyurt Department of Biochemistry, Gaziantep University School of Medicine, Gaziantep https://orcid.org/0000-0002-8248-5376
Beltinge Demircioğlu Kılıç Department of Pediatrics, Gaziantep https://orcid.org/0000-0001-9408-2139

DOI:

https://doi.org/10.5152/eurjther.2020.20019

Keywords:

Ataxia telangiectasia, heat shock protein 27, heat shock protein 60, chaperone, children

Abstract

Objective: This study aimed to measure the levels of heat shock proteins (HSP) 27 and 60 as mediators for hypoxia and tissue injury in pediatric patients with ataxia telangiectasia (AT). Another aim was to determine the prognostic role of HSP 27 and 60 in AT.
Methods: This study analyzed the data of AT patients (n=15) aged 4-16 years and of age-matched healthy controls (n=20). HSP 27 and 60 levels were measured from serum samples of AT patients using an enzyme-linked immunosorbent assay and compared with those of healthy controls.
Results: Serum levels of HSP 27 and 60 were higher in patients with AT than in age-matched healthy controls (p=0.010 and p=0.000, respectively).
Conclusion: In AT patients, levels of HSP 27 and 60 are increased to prevent tissue injury; therefore, treatment targeting HSPs may prevent disease progression and development of secondary malignancy in this patient population.

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