Clinical and Radiological Predictors of Positive Microbiological Yield in Vertebral Osteomyelitis: A Retrospective Cohort Study
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DOI:
https://doi.org/10.58600/eurjther2233Keywords:
biopsy, discitis, osteomyelitis, vertebra, spinal infectionAbstract
Objective: To evaluate demographic, laboratory, biopsy, and imaging variables as potential predictors of microbial identification in patients with suspected vertebral osteomyelitis, aiming to enhance diagnostic accuracy and optimize patient care.
Methods: This retrospective cohort study analyzed 83 patients who underwent image-guided percutaneous disc-space sampling between June 2020 and December 2023. Inclusion criteria were adults aged ≥18 years with imaging-based evidence of vertebral osteomyelitis and clinical suspicion of infection. Exclusion criteria were presence of known malignancy and non-infective causes. Demographics, clinical history, imaging, biopsy, and microbiology data were collected. Logistic regression analysis was used to identify predictors of positive microbiological yield.
Results: Microorganisms were identified in 32 of 83 cases (38.6%), with Mycobacterium tuberculosis being the most common pathogen identified (21.9%). Elevated C-reactive protein (CRP) levels, erythrocyte sedimentation rate (ESR), and paravertebral signal changes on MRI were associated with a positive culture yield. Multivariate analysis identified CRP as an independent predictor of positive microbiological results. CT-guided percutaneous biopsy was found to be safe, with no major complications reported.
Conclusion: CT-guided percutaneous biopsy is a reliable and safe diagnostic tool for identifying the causative pathogens in vertebral osteomyelitis. Elevated CRP levels were independently associated with positive microbiological yield, highlighting its role as a crucial predictor in clinical practice. These findings underscore the importance of incorporating CRP levels into the diagnostic process, potentially guiding the selection of patients for biopsy to improve the detection of infection.
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Sobottke R, Seifert H, Fätkenheuer G, Schmidt M, Gossmann A, Eysel P (2008) Current diagnosis and treatment of spondylodiscitis. Dtsch Arztebl Int 105:181-187. https://doi.org/10.3238/arztebl.2008.0181
Duarte RM, Vaccaro AR (2013) Spinal infection: state of the art and management algorithm. Eur Spine J 22:2787-2799. https://doi.org/10.1007/s00586-013-2850-1
Schinkel C, Gottwald M, Andress HJ (2003) Surgical treatment of spondylodiscitis. Surg Infect (Larchmt) 4:387-391. https://doi.org/10.1089/109629603322761445
Mylona E, Samarkos M, Kakalou E, Fanourgiakis P, Skoutelis A (2009) Pyogenic vertebral osteomyelitis: a systematic review of clinical characteristics. Semin Arthritis Rheum 39:10-17. https://doi.org/10.1016/j.semarthrit.2008.03.002
Cottle L, Riordan T (2008) Infectious spondylodiscitis. J Infect 56:401-412. https://doi.org/10.1016/j.jinf.2008.02.005
Sertic M, Parkes L, Mattiassi S, Pritzker K, Gardam M, Murphy K (2019) The Efficacy of Computed Tomography-Guided Percutaneous Spine Biopsies in Determining a Causative Organism in Cases of Suspected Infection: A Systematic Review. Can Assoc Radiol J 70:96-103. https://doi.org/10.1016/j.carj.2018.09.003
Gouliouris T, Aliyu SH, Brown NM (2010) Spondylodiscitis: update on diagnosis and management. J Antimicrob Chemother 65 Suppl 3:iii11-24. https://doi.org/10.1093/jac/dkq303
Renfrew DL, Whitten CG, Wiese JA, el-Khoury GY, Harris KG (1991) CT-guided percutaneous transpedicular biopsy of the spine. Radiology 180:574-576. https://doi.org/10.1148/radiology.180.2.2068332
Agarwal V, Wo S, Lagemann GM, Tsay J, Delfyett WT (2016) Image-guided percutaneous disc sampling: impact of antecedent antibiotics on yield. Clin Radiol 71:228-234. https://doi.org/10.1016/j.crad.2015.10.031
Modic MT, Feiglin DH, Piraino DW, Boumphrey F, Weinstein MA, Duchesneau PM, Rehm S (1985) Vertebral osteomyelitis: assessment using MR. Radiology 157:157-166. https://doi.org/10.1148/radiology.157.1.3875878
de Lucas EM, Gonzalez Mandly A, Gutierrez A, Pellon R, Martin-Cuesta L, Izquierdo J, Sanchez E, Ruiz E, Quintana F (2009) CT-guided fine-needle aspiration in vertebral osteomyelitis: true usefulness of a common practice. Clin Rheumatol 28:315-320. https://doi.org/10.1007/s10067-008-1051-5
Enoch DA, Cargill JS, Laing R, Herbert S, Corrah TW, Brown NM (2008) Value of CT-guided biopsy in the diagnosis of septic discitis. J Clin Pathol 61:750-753. https://doi.org/10.1136/jcp.2007.054296
Sehn JK, Gilula LA (2012) Percutaneous needle biopsy in diagnosis and identification of causative organisms in cases of suspected vertebral osteomyelitis. Eur J Radiol 81:940-946. https://doi.org/10.1016/j.ejrad.2011.01.125
Chew FS, Kline MJ (2001) Diagnostic yield of CT-guided percutaneous aspiration procedures in suspected spontaneous infectious diskitis. Radiology 218:211-214. https://doi.org/10.1148/radiology.218.1.r01ja06211
Lee HT, Sebro R (2020) Predictors of positive bone cultures from CT-guided bone biopsies performed for suspected osteomyelitis. J Med Imaging Radiat Oncol 64:313-318. https://doi.org/10.1111/1754-9485.13012
McNamara AL, Dickerson EC, Gomez-Hassan DM, Cinti SK, Srinivasan A (2017) Yield of Image-Guided Needle Biopsy for Infectious Discitis: A Systematic Review and Meta-Analysis. AJNR Am J Neuroradiol 38:2021-2027. https://doi.org/10.3174/ajnr.A5337
Pupaibool J, Vasoo S, Erwin PJ, Murad MH, Berbari EF (2015) The utility of image-guided percutaneous needle aspiration biopsy for the diagnosis of spontaneous vertebral osteomyelitis: a systematic review and meta-analysis. Spine J 15:122-131. https://doi.org/10.1016/j.spinee.2014.07.003
Michel SC, Pfirrmann CW, Boos N, Hodler J (2006) CT-guided core biopsy of subchondral bone and intervertebral space in suspected spondylodiskitis. AJR Am J Roentgenol 186:977-980. https://doi.org/10.2214/ajr.05.0109
Heyer CM, Al-Hadari A, Mueller KM, Stachon A, Nicolas V (2008) Effectiveness of CT-guided percutaneous biopsies of the spine: an analysis of 202 examinations. Acad Radiol 15:901-911. https://doi.org/10.1016/j.acra.2008.01.020
Torda AJ, Gottlieb T, Bradbury R (1995) Pyogenic vertebral osteomyelitis: analysis of 20 cases and review. Clin Infect Dis 20:320-328. https://doi.org/10.1093/clinids/20.2.320
Colmenero JD, Jiménez-Mejías ME, Sánchez-Lora FJ, Reguera JM, Palomino-Nicás J, Martos F, García de las Heras J, Pachón J (1997) Pyogenic, tuberculous, and brucellar vertebral osteomyelitis: a descriptive and comparative study of 219 cases. Ann Rheum Dis 56:709-715. https://doi.org/10.1136/ard.56.12.709
Mellado JM, Pérez del Palomar L, Camins A, Salvadó E, Ramos A, Saurí A (2004) MR imaging of spinal infection: atypical features, interpretive pitfalls and potential mimickers. Eur Radiol 14:1980-1989. https://doi.org/10.1007/s00330-004-2310-8
Sharif HS, Morgan JL, al Shahed MS, al Thagafi MY (1995) Role of CT and MR imaging in the management of tuberculous spondylitis. Radiol Clin North Am 33:787-804
Ross PM, Fleming JL (1976) Vertebral body osteomyelitis: spectrum and natural history. A retrospective analysis of 37 cases. Clin Orthop Relat Res:190-198
Berbari EF, Kanj SS, Kowalski TJ, Darouiche RO, Widmer AF, Schmitt SK, Hendershot EF, Holtom PD, Huddleston PM, 3rd, Petermann GW, Osmon DR, Infectious Diseases Society of A (2015) 2015 Infectious Diseases Society of America (IDSA) Clinical Practice Guidelines for the Diagnosis and Treatment of Native Vertebral Osteomyelitis in Adults. Clin Infect Dis 61:e26-46. https://doi.org/10.1093/cid/civ482
Ahuja N, Sharma H (2017) The effectiveness of computed tomography-guided biopsy for the diagnosis of spondylodiscitis: an analysis of variables affecting the outcome. Eur Rev Med Pharmacol Sci 21:2021-2026
Chong BSW, Brereton CJ, Gordon A, Davis JS (2018) Epidemiology, Microbiological Diagnosis, and Clinical Outcomes in Pyogenic Vertebral Osteomyelitis: A 10-year Retrospective Cohort Study. Open Forum Infect Dis 5:ofy037. https://doi.org/10.1093/ofid/ofy037
Ang MT, Wong GR, Wong DR, Clements W, Joseph T (2019) Diagnostic yield of computed tomography-guided biopsy and aspiration for vertebral osteomyelitis. J Med Imaging Radiat Oncol 63:589-595. https://doi.org/10.1111/1754-9485.12923
Marschall J, Bhavan KP, Olsen MA, Fraser VJ, Wright NM, Warren DK (2011) The impact of prebiopsy antibiotics on pathogen recovery in hematogenous vertebral osteomyelitis. Clin Infect Dis 52:867-872. https://doi.org/10.1093/cid/cir062
Diffre C, Jousset C, Roux AL, Duran C, Noussair L, Rottman M, Carlier RY, Dinh A (2020) Predictive factors for positive disco-vertebral biopsy culture in pyogenic vertebral osteomyelitis, and impact of fluoroscopic versus scanographic guidance. BMC Infect Dis 20:512. https://doi.org/10.1186/s12879-020-05223-z
Chang CY, Simeone FJ, Nelson SB, Taneja AK, Huang AJ (2015) Is Biopsying the Paravertebral Soft Tissue as Effective as Biopsying the Disk or Vertebral Endplate? 10-Year Retrospective Review of CT-Guided Biopsy of Diskitis-Osteomyelitis. AJR Am J Roentgenol 205:123-129. https://doi.org/10.2214/ajr.14.13545
Peckham ME, Shah LM, Johnson SM, Ryals E, Noda G, Hutchins TA (2021) Defining Disc Biopsy Timing in Relation to Blood Culture Results for Inpatients with Suspected Discitis-Osteomyelitis. J Vasc Interv Radiol 32:121-127. https://doi.org/10.1016/j.jvir.2020.08.020
Lopes Floro K, Munckhof W, Coucher J (2018) Retrospective review of CT-guided intervertebral disc biopsies performed at a tertiary referral centre for suspected osteodiscitis. J Med Imaging Radiat Oncol 62:307-312. https://doi.org/10.1111/1754-9485.12686
Kuo AH, Cho CH, Huang RY, Kim CJ, Lee TC (2020) Target-specific yield rate and clinical utility of percutaneous tissue sampling in spinal infection. Clin Imaging 68:257-262. https://doi.org/10.1016/j.clinimag.2020.08.025
Hoang D, Fisher S, Oz OK, La Fontaine J, Chhabra A (2019) Percutaneous CT guided bone biopsy for suspected osteomyelitis: Diagnostic yield and impact on patient's treatment change and recovery. Eur J Radiol 114:85-91. https://doi.org/10.1016/j.ejrad.2019.01.032
Schirò S, Foreman SC, Bucknor M, Chin CT, Joseph GB, Link TM (2020) Diagnostic Performance of CT-Guided Bone Biopsies in Patients with Suspected Osteomyelitis of the Appendicular and Axial Skeleton with a Focus on Clinical and Technical Factors Associated with Positive Microbiology Culture Results. J Vasc Interv Radiol 31:464-472. https://doi.org/10.1016/j.jvir.2019.08.013
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