Effect of Past and Current Dental Treatment on Children’s Dental Anxiety Status and Oxidative Stress Biomarkers: A Pilot Study

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Dental anxiety, oxidative stress, dental treatment, anxiety scale


Objective: This study aimed to detect dental anxiety caused by past and current dental treatment in children using saliva biomarkers and to investigate the correlation between these markers and psychometric analysis.
Methods: A total of 43 children aged 6–13 years were recruited for this study. The participants were divided into two groups: those with dental treatment experience (G1) and those who presented to the dentist for the first time (G2). Anxiety scale data and saliva samples were obtained. Oxidative stress (OS) markers, namely, total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI), were analyzed from the saliva samples. After current treatments such as fluoride application or restorative procedures, anxiety scale data, and saliva samples were obtained.
Results: TAC and OSI values were higher in G1 than in G2 at baseline (p<0.05), and anxiety scale values were similar in both groups (p>0.05). After the current treatment, a significant decrease in TAC and OSI values was found in G1 (p<0.05), but no significant difference was observed in G2. Anxiety scale values were significantly decreased after treatment in G2 (p<0.05). Although a strong correlation was found between baseline TAC, TOS, OSI, and post-treatment TAC and OSI values (p<0.001), no correlation was noted between OS biomarkers and anxiety scale values (p>0.05).
Conclusion: These results suggested a potential relationship between anxiety and OS biomarkers, but additional studies are needed to understand the relationship between dental anxiety and pathophysiological changes in OS biomarkers.


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How to Cite

Keskin, G., Gündoğar, Z. U., Çiloğlu, M., Ulusal, H., & Gündoğar, H. (2020). Effect of Past and Current Dental Treatment on Children’s Dental Anxiety Status and Oxidative Stress Biomarkers: A Pilot Study. European Journal of Therapeutics, 26(4), 282–286. https://doi.org/10.5152/eurjther.2020.20018



Original Articles