Changes in Plasma Amino Acid Levels in Crimean-Congo Hemorrhagic Fever Patients

Zeynep Ertemür; Hüseyin Aydın; Aynur Engin

doi:10.58600/eurjther2112

Authors

Zeynep Ertemür Department of Infectious Diseases and Surveillance, Sivas Cumhuriyet University Faculty of Medicine Hospital, Sivas, Türkiye https://orcid.org/0000-0002-7365-9581
Hüseyin Aydın Department of Biochemistry, Sivas Cumhuriyet University Faculty of Medicine, Sivas, Türkiye https://orcid.org/0000-0002-3194-830X
Aynur Engin Department of Infectious Diseases and Clinical Microbiology, Istanbul Yeni Yuzyil University Faculty of Medicine, Istanbul, Türkiye https://orcid.org/0000-0002-8533-8793

DOI:

https://doi.org/10.58600/eurjther2112

Keywords:

biochemical analysis, Crimean‐Congo hemorrhagic fever virus, metabolic analysis, research andanalysis methods

Abstract

Objective: Crimean Congo Hemorrhagic Fever (CCHF) has an important place in viral hemorrhagic fever. Plasma amino acid (AA) levels of patients who were diagnosed with CCHF in the acute and convalescent period of the disease were investigated in this study.

Methods: 35 patients were included in the study specific polymerase chain reaction (PCR) and/or IgM antibody positivity for CCHF virus. AA levels were measured in the plasma derived from the blood samples of the patient and control groups, using liquid chromatography-mass spectrometry (LC-MS/MS) technique.

Results: In our study, we observed that plasma aspartate, glutamate, histidine, leucine, phenylalanine, tyrosine levels increased statistically significantly (p<0.05), while some AA levels decreased (p<0.05) in acute stage patients compared to the control groups. In addition, while there was an increase in plasma glutamate levels of convalescent patients compared to the control groups (p<0.05), there was a significant decrease in other AA levels (p<0.05).

Conclusion: Further studies to investigate the relationship between increased or decreased AAs in the plasma levels of these patients and the immune system are likely to contribute to a better understanding of the pathogenesis of the disease and to guide the approach to whether AA supplementation is necessary for treatment.

Keywords: biochemical analysis, Crimean‐Congo hemorrhagic fever virus, metabolic analysis, research andanalysis methods

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References

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