Protective Effect of Pomegranate Juice on Lead Acetate-Induced Liver Toxicity in Male Rats

Hıdır Pekmez; Ebru Annaç; Özgür Bulmuş; Büşra Zencirci; Merve Aydın; Ali Aydın

doi:10.58600/eurjther1927

Authors

Hıdır Pekmez Department of Anatomy, Faculty of Medicine, Malatya Turgut Özal University, Malatya, Türkiye https://orcid.org/0000-0002-4916-7675
Ebru Annaç Department of Histology and Embryology, Faculty of Medicine, Adıyaman University, Adıyaman, Türkiye https://orcid.org/0000-0001-9726-5846
Özgür Bulmuş Department of Physiology, Faculty of Medicine, Balıkesir University, Balıkesir, Türkiye https://orcid.org/0000-0001-7736-402X
Büşra Zencirci Department of Anatomy, Faculty of Medicine, Adıyaman University, Adıyaman, Türkiye https://orcid.org/0000-0002-6015-3047
Merve Aydın Department of Anatomy, Faculty of Medicine, Malatya Turgut Özal University, Malatya, Türkiye https://orcid.org/0000-0001-6221-4424
Ali Aydın Department of Anatomy, Faculty of Medicine, Adıyaman University, Adıyaman, Türkiye https://orcid.org/0000-0003-2464-4743

DOI:

https://doi.org/10.58600/eurjther1927

Keywords:

Antioxidant, Lead acetate, Liver, Pomegranate juice, Oxidative stress

Abstract

Objective: Lead has been reported to cause oxidative stress in liver tissues and cause histopathological changes. Studies have shown that pomegranate juice has antioxidant properties that prevent oxidative stress. In this study, the harmful effects of lead acetate on rat liver tissue and the efficacy of pomegranate juice against these effects were investigated.

Methods: 28 male Wistar albino rats were divided into four groups: control, lead acetate (50 mL/kg), pomegranate juice (1 mL/kg), and lead acetate + pomegranate juice (50 mL/kg+1 mL/kg). Lead acetate and pomegranate juice were administered orally.

Results: When compared with the control group, it was seen that the lead acetate had an increase in the malondialdehyde level and a decrease in reduced Glutathione, Glutathione S-transferase, and Carboxylesterases. Group lead acetate + pomegranate juice had a reduction in malondialdehyde level and an increase in Glutathione, Glutathione S-transferase, and Carboxylesterases compared with the group lead acetate. The lead level of group lead acetate + pomegranate juice decreased compared to the group lead acetate. Cellular degeneration and irregular hepatic cords were observed in group lead acetate's liver tissue, and the negative changes were lost in group lead acetate + pomegranate juice.

Conclusion: It was observed that pomegranate juice had a protective effect against liver toxicity caused by lead acetate.

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