The Use of Herbal Products/Dietary Supplements and Affecting Factors in Patients Applying to a Pediatric Neurology Outpatient Clinic: A Descriptive Questionnaire Study
Abstract views: 302 / PDF downloads: 176
DOI:
https://doi.org/10.58600/eurjther1858Keywords:
epilepsy, herbal products, dietary supplements, herb-drug interaction, pediatric neurologyAbstract
Objectives: The use of herbal products/dietary supplements (HP/DS) in the pediatric population is increasing day by day. The interaction of HP/DSs with drugs with a narrow therapeutic index such as phenytoin, phenobarbital, and valproic acid, may cause problems in treatment. In this respect, it is very important to determine the use of HP/DS in children with neurological diseases and/or complaints. In this study, it was aimed to determine the use of HP/DS and the factors affecting the use of these products in individuals with a neurological complaint and/or disease who applied to the pediatric neurology outpatient clinic.
Methods: Parents were questioned face-to-face as part of the descriptive questionnaire research. 174 questionnaires with appropriate data quality were included in the study. The statistical software tool SPSS 23.0 was used to analyze the data.
Results: 44.6% of the parents stated that they gave HP/DS to their children. The findings of the analysis showed that kids whose parents use HP/DS are more likely to utilize these items themselves (p<0.001). The most commonly used products are linden (70.1%), bee products (26.0%), carob (18.2%), chamomile (13.0%), and lemon (13.0%). It has been determined that the reasons for parents to have their children use HP/DS are to strengthen the immune system (51.9%), improve general health status (40.3%), and supplement normal nutrition (27.3%), respectively.
Conclusions: This study revealed a high frequency of HP/DS use in children with pediatric neurological diseases/complaints in Türkiye. The frequency of HP/DS use was higher in children whose parents tended to consume HP/DS. Considering the high use of these products, healthcare professionals need to inform parents to prevent adverse effects caused by HP/DS.
Metrics
References
Chikezie PC, Ojiako OA (2015) Herbal Medicine: Yesterday, today and tomorrow. Altern Integr Med 4:3. https://doi.org/10.4172/2327-5162.1000195
World Health Organization & WHO Expert Committee on Specifications for Pharmaceutical Preparations (2018) Fifty-second report of the WHO Expert Committee on specifications for pharmaceutical preparations. Available from https://apps.who.int/iris/bitstream/handle/10665/272452/9789241210195-eng.pdf?sequence=1&isAllowed=y Accessed 1 March 2022
Disli M, Yesilada E (2019) Herbal medicinal products in Turkey (Standardization, production and adulteration of herbal products in Turkey). J Biotechnol and Strategic Health Res 3(Special Issue):13-21. https://doi.org/10.34084/bshr.545498
Türkiye Cumhuriyeti Tarım ve Orman Bakanlığı (2013) Türk Gıda Kodeksi Takviye Edici Gıdalar Tebliği. Available from https://www.resmigazete.gov.tr/eskiler/2013/08/20130816-16.htm Accessed 1 March 2022
Wegener T (2013) Herbal medicinal products in the pediatric population-status quo and perspectives. Wien Med Wochenschr 163(3-4):46-51. https://doi.org/10.1007/s10354-013-0175-7
Zhang Y, Fein EB, Fein SB (2011) Feeding of dietary botanical supplements and teas to infants in the United States. Pediatrics 127(6):1060-1066. https://doi.org/10.1542/peds.2010-2294
Bulut S, Karakas NM, Deliorman Orhan D (2021) Evaluation of plant and herbal product usage habits in pediatric patients. Health and Society 31(2):172-180.
Zhu Z, Mittal R, Walser SA, Lehman E, Kumar A, Paudel S, Mainali G (2022) Complementary and alternative medicine (CAM) use in children with epilepsy. J Child Neurol 37(5):334-339. https://doi.org/10.1177/08830738211069790
Oskoui M, Ng P, Zaman M, Buckley D, Kirton A, van Rensburg E, Wood E, Shevell M, Majnemer A (2021) Complementary and alternative therapy use in children with cerebral palsy. Can J Neurol Sci 48(3):408-414. https://doi.org/10.1017/cjn.2020.188.
Sinha D, Efron D (2005) Complementary and alternative medicine use in children with attention deficit hyperactivity disorder. J Paediatr Child Health 41(1-2):23-26. https://doi.org/10.1111/j.1440-1754.2005.00530.x
Soo I, Mah JK, Barlow K, Hamiwka L, Wirrell E (2005) Use of complementary and alternative medical therapies in pediatric neurology clinic. Can J Neurol Sci 32(4):524-528. https://doi.org/10.1017/s0317167100004558
Chen C, Chong YJ, Hie SL, Sultana R, Lee SHD, Chan WSD, Chan SY, Cheong HH (2016) Complementary and alternative medicines use among pediatric patients with epilepsy in a multiethnic community. Epilepsy Behav 60:68-74. https://doi.org/10.1016/j.yebeh.2016.04.008
Lee JY, Choi WS, Eun SH, Eun BL, Hong YS, Lee JW (2008) Use of herbal medicine in epileptic children. Clin Exp Pediatr 51(4):415-419. https://doi.org/10.3345/kjp.2008.51.4.415
OpenEpi. Available from https://www.openepi.com/SampleSize/SSPropor.htm Accessed 05 April 2021
Pars H, Suluhan D, Ercan E (2020) Use of traditional complementary treatment by the mothers with asthmatic children and the effect of their knowledge about the disease on the control of asthma: a single-center experience. J Tradit Complem Med 3(1):1-10. https://doi.org/10.5336/jtracom.2019-71931
Galicia-Connolly E, Adams D, Bateman J, Dagenais S, Clifford T, Baydala L, King WJ, Vohra S (2014) CAM use in pediatric neurology: an exploration of concurrent use with conventional medicine. PLoS One 9(4):e94078. https://doi.org/10.1371/journal.pone.0094078
Al-Rumayyan A, Alqarni H, Almanna BS, Althonayan N, Alhalafi M, Alomary N (2020) Utilization of complementary medicine by pediatric neurology patients and their families in Saudi Arabia. Cureus 12(5):e7960. https://doi.org/10.7759/cureus.7960
Carman KB, Lacinel-Gurlevik S, Kaplan E, Dinleyici M, Yarar C, Arslantas D (2018) The evaluation of use of complementary and alternative medicine practices in the treatment of children with chronic neurological disease. Haydarpasa Numune Med J 58(3):117-121. https://doi.org/10.14744/hnhj.2018.43265
Doering JH, Reuner G, Kadish NE, Pietz J, Schubert-Bast S (2013) Pattern and predictors of complementary and alternative medicine (CAM) use among pediatric patients with epilepsy. Epilepsy Behav 29(1):41-46. https://doi.org/10.1016/j.yebeh.2013.06.025
Jeong MJ, Lee HY, Lim JH, Yun YJ (2016) Current utilization and influencing factors of complementary and alternative medicine among children with neuropsychiatric disease: a cross-sectional survey in Korea. BMC Complement Altern Med 16:91. https://doi.org/10.1186/s12906-016-1066-4
Hartmann N, Neininger MP, Bernhard MK, Syrbe S, Nickel P, Merkenschlager A, Kiess W, Bertsche T, Bertsche A (2016) Use of complementary and alternative medicine (CAM) by parents in their children and adolescents with epilepsy - Prevelance, predictors and parents' assessment. Eur J Paediatr Neurol 20(1):11-19. https://doi.org/10.1016/j.ejpn.2015.11.003
Naja F, Alameddine M, Abboud M, Bustami D, Al Halaby R (2011) Complementary and alternative medicine use among pediatric patients with leukemia: the case of Lebanon. Integr Cancer Ther 10(1):38-46. https://doi.org/10.1177/1534735410384591
Yeon GM, Nam SO (2016) The use of complementary and alternative medicine in children with common neurologic diseases. Korean J Pediatr 59(8):313-318. https://doi.org/10.3345/kjp.2016.59.8.313
Tuncel T, Sen V, Kelekci S, Karabel M, Sahin C, Uluca U, Karabel D, Haspolat YK (2014) Use of complementary and alternative medicine in children who have no chronic disease. Turk Arch Pediatr 49(2):148-153. https://doi.org/10.5152/tpa.2014.1498
Du Y, Wolf IK, Zhuang W, Bodemann S, Knöss W, Knopf H (2014) Use of herbal medicinal products among children and adolescents in Germany. BMC Complement Altern Med 14:218. https://doi.org/10.1186/1472-6882-14-218
Hanson E, Kalish LA, Bunce E, Curtis C, McDaniel S, Ware J, Petry J (2007) Use of complementary and alternative medicine among children diagnosed with autism spectrum disorder. J Autism Dev Disord 37(4):628-636. https://doi.org/10.1007/s10803-006-0192-0
Davis MP, Darden PM (2003) Use of complementary and alternative medicine by children in the United States. Arch Pediatr Adolesc Med 157(4):393-396. https://doi.org/10.1001/archpedi.157.4.393
Birdee GS, Phillips RS, Davis RB, Gardiner P (2010) Factors associated with pediatric use of complementary and alternative medicine. Pediatrics 125(2):249-256. https://doi.org/10.1542/peds.2009-1406
Liao HH, Yen HR, Muo CH, Lee YC, Wu MY, Chou LW, Sun MF, Chang TT (2017) Complementary traditional Chinese medicine use in children with cerebral palsy: a nationwide retrospective cohort study in Taiwan. BMC Complement Altern Med 17(1):155. https://doi.org/10.1186/s12906-017-1668-5
Dulger G (2012) Herbal drugs and drug interactions. Marmara Pharm J 16:9-22. https://doi.org/10.12991/201216415
Garg SK, Kumar N, Bhargava VK, Prabhakar SK (1998) Effect of grapefruit juice on carbamazepine bioavailability in patients with epilepsy. Clin Pharmacol Ther 64(3):286-288. https://doi.org/10.1016/S0009-9236(98)90177-1
Gurley B, Hubbard MA, Williams DK, Thaden J, Tong Y, Gentry WB, Breen P, Carrier DJ, Cheboyina S (2006) Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: comparison of a milk thistle and black cohosh product to rifampin and clarithromycin. J Clin Pharmacol 46(2):201-213. https://doi.org/10.1177/0091270005284854
Lilja JJ, Backman JT, Neuvonen PJ (2007) Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam--probes of CYP2C9, CYP1A2, and CYP3A4. Clin Pharmacol Ther 81(6):833-839. https://doi.org/10.1038/sj.clpt.6100149
Wongnawa M, Soontaro P, Riditid W, Wongpoowarak P, Ruengkittisakul S (2012) Andrographis paniculata (Burm.f.) Nees on the pharmacokinetics and pharmacodynamics of midazolam in healthy volunteers. Songklanakarin J Sci Technol 34(5):533-539.
Johannessen Landmark C, Patsalos PN (2008) Interactions between antiepileptic drugs and herbal medicines. Bol Latinoam Caribe Plant Med Aromaticas 7(2):109-118.
Kupiec T, Raj V (2005) Fatal seizures due to potential herb-drug interactions with Ginkgo biloba. J Anal Toxicol 29(7):755-758. https://doi.org/10.1093/jat/29.7.755
Mochizuki K, Hamano Y, Miyama H, Arakawa K, Kobayashi T, Imamura H (2015) Successful treatment of a case with concurrent ingestion of carbamazepine overdose and grapefruit juice. Acute Med Surg 3(1):36-38. https://doi.org/10.1002/ams2.117
Lantz MS, Buchalter E, Giambanco V (1999) St. John’s wort and antidepressant drug interactions in the elderly. J Geriatr Psychiatry Neurol 12:7-10. https://doi.org/10.1177/089198879901200103
Williamson EM, Driver SM, Baxter K (2009) Stockley’s herbal medicines interactions: A guide to the interactions of herbal medicines, dietary supplements and nutraceuticals with conventional medicines, 2nd edn. pp:360-380, Pharmaceutical Press, London.
Downloads
Published
How to Cite
License
Copyright (c) 2023 European Journal of Therapeutics
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
The content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.