Current Bio-based Cements and Radioactive Opacifiers in Endodontic Approaches: A Review of the Materials Used in Clinical Practice

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Bioceramics, Biomimetic materials, Endodontics, Radiopacifiers


Objective: This study aims to evaluate the importance of endodontic root canal sealers in filling cavities and irregularities in root canals with the primary goal of minimizing or eliminating bacterial residues. Despite this crucial objective, it's noteworthy that several conventional sealers have been linked to adverse effects, such as impaired wound healing, inflammation, and bone resorption. Therefore, there is a constant search for an optimal sealer that can effectively mimic the properties of lost tissue while maintaining an acceptable level of biological, physicochemical and biocompatible properties. The present study analyzes bioceramic cement's properties in endodontics through a comprehensive review of the available literature. Also, to evaluate the beneficial properties and characteristics of the biomaterials highlighted in this work.

Methods: The present study used a systematic review approach to conduct a comprehensive literature search to find relevant publications on bioceramic cement properties in the endodontics field. Articles were retrieved using MeSH keywords and digital searches of journal websites. The selected studies were examined to extract data on sealability, bioactivity, pH, cytotoxicity, color change, radiopacity, edge adaptation, adhesive strength, antibacterial properties and biocompatibility.

Results: The results of the reviewed research show that bioceramic endodontic cement has favorable properties for the therapeutic treatment of root canals. The literature highlights the material's biocompatibility, low cytotoxicity, bioactivity, radiopacity, appropriate pH value, favorable edge adaptation, high adhesive strength, practical sealability, antibacterial properties and minimal color change.

Conclusion: Research results to date indicate that biomaterials used in endodontics have beneficial properties for root canal therapy and mimicking natural tissue regeneration. The beneficial properties of these materials, such as their biocompatibility, bioactivity, radiopacity, pH stability, edge conformability, adhesion strength, sealability and antibacterial properties, make it a promising replacement for traditional sealers. Further studies are needed to investigate the extended clinical effectiveness of the above intervention and to refine its composition to improve the outcomes associated with endodontic therapies.


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Author Biography

A.Najah Saud, Department of Biomedical Engineering, Faculty of Engineering, Karabük University, Turkey

Biomedical Engineering, Al-Mustaqbal University College, Babylon, Iraq


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How to Cite

Saud, A., Koç , E., & Özdemir, O. (2023). Current Bio-based Cements and Radioactive Opacifiers in Endodontic Approaches: A Review of the Materials Used in Clinical Practice. European Journal of Therapeutics, 29(4), 930–951.



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