Effects of Pinealectomy and Melatonin Application on Serum Melatonin, Nesfatin-1 and Ghrelin Levels

Saadet Sonmez; Esma Menevse; Saltuk Bugra Baltaci; Omer Unal; Rasim Mogulkoc; Abdulkerim Kasim Baltaci

doi:10.58600/eurjther1747

Authors

Saadet Sonmez Faculty of Medicine, Department of Physiology, Selcuk University, Konya, Turkey https://orcid.org/0000-0001-8952-9952
Esma Menevse Faculty of Medicine, Department of Biochemistry, Selcuk University, Konya, Turkey https://orcid.org/0000-0002-5477-5667
Saltuk Bugra Baltaci Department of Physiology, Regenerative and Restorative Medical Research Center, Istanbul Medipol University, Istanbul, Turkey https://orcid.org/0000-0002-9752-7508
Omer Unal Kırıkkale University, Medical Faculty, Department of Physiology, Kırıkkale, Turkey https://orcid.org/0000-0003-4420-5924
Rasim Mogulkoc Faculty of Medicine, Department of Physiology, Selcuk University, Konya, Turkey https://orcid.org/0000-0001-6155-6780
Abdulkerim Kasim Baltaci Faculty of Medicine, Department of Physiology, Selcuk University, Konya, Turkey https://orcid.org/0000-0003-2461-1212

DOI:

https://doi.org/10.58600/eurjther1747

Keywords:

Pinealectomy, melatonin, nutrition, nesfatin-1, ghrelin, rat

Abstract

Objective: In this study, it was aimed to investigate the relationship between the pineal gland and ghrelin and nesfatin-1 hormones in rats.

Methods: A total of 36 male rats were used in the study, and the animals were divided into 4 groups. Group 1, Control; Group 2, Pinealectomy (Px); Group 3, Px+Melatonin; Group 4 Melatonin. After the end of the experimental applications, melatonin, ghrelin and nesfatin-1 levels (ELISA) were determined in the blood samples taken from the animals.

Results: While pinealectomy resulted in suppression of melatonin levels, melatonin supplementation led to a significant increase in blood melatonin levels (p<0.01). Melatonin supplementation suppressed ghrelin levels, while pinealectomy increased ghrelin levels (P<0.01). On the other hand, Nesfatin-1 levels, which increased with melatonin support, were significantly suppressed by pinealectomy (p<0.01).

Conclusion: The results of the current study show that the pineal gland may have important effects on the hormones ghrelin and nesfatin-1, which play critical roles in nutrition. In conclusion melatonin supplementation inhibites ghrelin, and but increases nesfatin-1.

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References

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