Effects of Pinealectomy and Melatonin Application on Serum Melatonin, Nesfatin-1 and Ghrelin Levels

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Pinealectomy, melatonin, nutrition, nesfatin-1, ghrelin, rat


Objective: In this study, it was aimed to investigate the relationship between the pineal gland and ghrelin and nesfatin-1 hormones in rats.

Methods: A total of 36 male rats were used in the study, and the animals were divided into 4 groups. Group 1, Control; Group 2, Pinealectomy (Px);  Group 3, Px+Melatonin; Group 4 Melatonin.  After the end of the experimental applications, melatonin, ghrelin and nesfatin-1 levels (ELISA) were determined in the blood samples taken from the animals.

Results: While pinealectomy resulted in suppression of melatonin levels, melatonin supplementation led to a significant increase in blood melatonin levels (p<0.01). Melatonin supplementation suppressed ghrelin levels, while pinealectomy increased ghrelin levels (P<0.01). On the other hand, Nesfatin-1 levels, which increased with melatonin support, were significantly suppressed by pinealectomy (p<0.01).

Conclusion: The results of the current study show that the pineal gland may have important effects on the hormones ghrelin and nesfatin-1, which play critical roles in nutrition. In conclusion melatonin supplementation inhibites ghrelin, and but increases nesfatin-1.


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How to Cite

Sonmez, S., Menevse, E., Baltaci, S. B., Unal, O., Mogulkoc, R., & Baltaci, A. K. (2023). Effects of Pinealectomy and Melatonin Application on Serum Melatonin, Nesfatin-1 and Ghrelin Levels. European Journal of Therapeutics, 29(3), 526–533. https://doi.org/10.58600/eurjther1747



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