Scientometric Research Analysis of Cleft Lip and Palate Literature: Hot Spots, Most Influential Countries/Journals, History and Future

Abstract views: 301 / PDF downloads: 148


  • Yunus Balel Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tokat Gaziosmanpaşa University, Tokat, Türkiye and T.R. Ministry of Health, Sivas Oral and Dental Health Hospital, Sivas, Türkiye



Cleft lip, Cleft palate, Scientometric


Objective: Identifying and mapping the hotspots of the Cleft lip and palate (CLP) literature from 1980 to 2022, in addition it is aimed to present the results in a simplification. This article aims to offer an overview of pertinent research, examine prevailing research patterns, and stimulate appropriate areas for future investigation.

Methods: In this scientometric research analysis, CLP publications between 1980 and 2022 were obtained from the Web of Science Core Collection database. The keywords "cleft lip and palate", "cleft lip, "cleft palate" and "oral cleft" were used in the search. CiteSpace, R-Studio (biblioshiny program) and Excel 2016 software were used for visualizations and analysis.

Results: A total of 26,319 articles and 473,074 references were analyzed. The top 3 countries with the most publications were the United States (9,368 publications, 35.59% of the total), the United Kingdom (2,062, 7.83%), and Japan (1,786, 6.78%). After the co-citation clustering analysis, it was seen that the CLP literature was divided under 13 headings. The most influential articles were found with the citation burst analysis.

Conclusion: Scientometric analysis study has been done in CLP's 42-year publication history. The results obtained present the general trend of the CLP literature, the topics on which the literature is divided, and the hot spots. With similar scientometric analysis studies to be carried out in the future, the progress of the literature can be followed and the future can be predicted.


Metrics Loading ...


Zhang Q, Yue Y, Shi B, Yuan Z (2019) A Bibliometric Analysis of Cleft Lip and Palate-Related Publication Trends From 2000 to 2017. Cleft palate-craniofacial J. 56(5):658–669.

Worley ML, Patel KG, Kilpatrick LA (2018) Cleft Lip and Palate. Clin Perinatol. 45(4):661–678.

Balel Y (2021) A bibliometric analysis of international publication trends in impacted third molar surgery research (2000–2020). Br J Oral Maxillofac Surg. 59(10):1220-1226.

Balel Y (2023) The Last 40 Years of Orthognathic Surgery: A Bibliometric Analysis. J Oral Maxillofac Surg.

Grillo R, Al-Moraissi E, Balel Y, et al (2022) Oral and maxillofacial literature from Middle East: a bibliometric analysis and list of top-100 most cited articles. J Stomatol Oral Maxillofac Surg.

Tekin AM, Bahşi I (2021) Global Research on Maxillofacial Fracture Over the Last 40 Years: A Bibliometric Study. J Craniofac Surg. 32(6):568-572.

Adanır SS, Bahşi İ, Kervancıoğlu P, et al (2020) Bibliometric analysis of articles published in Anatomy, the official publication of the Turkish Society of Anatomy and Clinical Anatomy between 2007–2018. Anatomy. 14(1):39–43.

Balel Y, Tümer MK (2021) A bibliometric analysis of international publication trends in Total Temporomandibular Joint Replacement research (1986–2020). J Oral Maxillofac Surg. 79(7):1458-e1.

Balel Y (2023) Global Mapping Analysis of Maxillofacial Trauma Literature From 1980-2022. Eur J Ther.

Mahon NA, Joyce CW (2015) A bibliometric analysis of the 50 most cited papers in cleft lip and palate. J Plast Surg Hand Surg. 49(1):52–58.

Boyack KW, Klavans R (2010) Co-citation analysis, bibliographic coupling, and direct citation: Which citation approach represents the research front most accurately? J Am Soc Inf Sci Technol. 61(12):2389–2404.

Baldock C, Ma R, Orton CG (2009) The index is the best measure of a scientist’s research productivity. Med Phys. 36(4):1043–1045.

Trujillo CM, Long TM (2018) Document co-citation analysis to enhance transdisciplinary research. Sci Adv. 4(1):e1701130.

Grillo R, Balel Y, Brozoski MA, et al (2023) A global science mapping analysis on odontogenic infections. J Stomatol Oral Maxillofac Surg.

Amjad T, Shahid N, Daud A, Khatoon A (2022) Citation burst prediction in a bibliometric network. Scientometrics. 127(5):2773–2790.

Dixon MJ, Marazita ML, Beaty TH, Murray JC (2011) Cleft lip and palate: understanding genetic and environmental influences. Nat Rev Genet. 12(3):167–178.

Williams C, Harding S, Wren Y (2021) An Exploratory Study of Speech and Language Therapy Intervention for Children Born With Cleft Palate ± Lip. Cleft palate-craniofacial J. 58(4):455–469.

Kummer AW (2011) Speech therapy for errors secondary to cleft palate and velopharyngeal dysfunction. Semin Speech Lang. 32(2):191–198.

Kapp-Simon KA (2004) Psychological issues in cleft lip and palate. Clin Plast Surg. 31(2):347–352.

Al-Namankany A, Alhubaishi A (2018) Effects of cleft lip and palate on children’s psychological health: A systematic review. J Taibah Univ Med Sci. 13(4):311–318.

Bessell A, Sell D, Whiting P, et al (2013) Speech and Language Therapy Interventions for Children with Cleft Palate: A Systematic Review. Cleft Palate-Craniofacial J. 50(1):1–17.

Meinusch M, Romonath R (2011) Early language intervention for children with cleft lip and/or palate: A systematic review. Evid Based Commun Assess Interv. 5(4):197–215.

Mossey PA, Modell B (2012) Epidemiology of oral clefts 2012: an international perspective. Front Oral Biol 16:1–18.

Parwaz MA, Sharma RK, Parashar A, et al (2009) Width of cleft palate and postoperative palatal fistula--do they correlate? J Plast Reconstr Aesthet Surg. 62(12):1559–1563.

Ardinger HH, Buetow KH, Bell GI, et al (1989) Association of genetic variation of the transforming growth factor-alpha gene with cleft lip and palate. Am J Hum Genet. 45(3):348–353

Murray JC (2002) Gene/environment causes of cleft lip and/or palate. Clin Genet. 61(4):248–256.

Abyholm FE, Bergland O, Semb G (1981) Secondary bone grafting of alveolar clefts. A surgical/orthodontic treatment enabling a non-prosthodontic rehabilitation in cleft lip and palate patients. Scand J Plast Reconstr Surg. 15(2):127–140.

Semb G (1991) A study of facial growth in patients with bilateral cleft lip and palate treated by the Oslo CLP Team. Cleft palate-craniofacial J. 28(1):22–28.

Yu Y, Zuo X, He M, et al (2017) Genome-wide analyses of non-syndromic cleft lip with palate identify 14 novel loci and genetic heterogeneity. Nat Commun. 8:14364.

Zucchero TM, Cooper ME, Maher BS, et al (2004) Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate. N Engl J Med. 351(8):769–780.

Gritli-Linde A (2007) Molecular control of secondary palate development. Dev Biol. 301(2):309–326.

Longaker MT, Whitby DJ, Adzick NS, et al (1990) Studies in fetal wound healing, VI. Second and early third trimester fetal wounds demonstrate rapid collagen deposition without scar formation. J Pediatr Surg. 25(1):63–69.

Tyan ML, Miller KK (1978) Genetic and environmental factors in cortisone induced cleft palate. Proc Soc Exp Biol Med Soc Exp Biol Med. 158(4):618–621.

Goldberg R, Motzkin B, Marion R, et al (1993) Velo-cardio-facial syndrome: a review of 120 patients. Am J Med Genet. 45(3):313–319.

Figure 1




How to Cite

Balel, Y. (2023). Scientometric Research Analysis of Cleft Lip and Palate Literature: Hot Spots, Most Influential Countries/Journals, History and Future. European Journal of Therapeutics, 30(1), 48–59.