The Effect of Zinc on The Isolated Frog Gastrocnemius Muscle

Nurcan DURSUN; Asuman GÖLGELİ; Cem SÜER; Çiğdem ÖZESMİ; Sami AYDOĞAN

doi:10.58600/eurjther.1995-6-1-1581-arch

Authors

Nurcan DURSUN Erciyes Üniversitesi Tıp Fakültesi Fizyoloji ABD.Yrd.Doç.Dr.
Asuman GÖLGELİ Erciyes Üniversitesi Tıp Fakültesi Fizyoloji ABD.Öğr.Üyesi
Cem SÜER Erciyes Üniversitesi Tıp Fakültesi Fizyoloji ABD.Doç.Dr.
Çiğdem ÖZESMİ Erciyes Üniversitesi Tıp Fakültesi Fizyoloji ABD.Prof.Dr.
Sami AYDOĞAN Erciyes Üniversitesi Tıp Fakültesi Fizyoloji ABD.Prof.Dr.

DOI:

https://doi.org/10.58600/eurjther.1995-6-1-1581-arch

Keywords:

Zinc, Skeletal Muscle, Twitch Characteristics, Frog, in Vitro

Abstract

The effect of zinc was studied on isolated frog gastrocnemius muscle wich was stimulated directly or indirectly and perfused with frog Ringer containing calcium(Ca2+) or deplated of Ca2 +. N.ischiadicus-gastrocnemius muscles were obtained from 15 frogs. Isometric force generated in response to supramaximal electrical stimulation was measured with a transducer and peak tension(Pt), contraction time(CT) and total contraction time(TCT) were analyzed by a polygraphic system and a computer. Zinc increased Pt in a concentration dependent manner, but no change was observed in er and total contraction time. We suggested that zinc might affect the striated muscle by intracellular mechanism(s).

Metrics

Metrics Loading ...

References

- Hede SS, Dınız R5, Agshıkar NV and Dhume VG:Dual action zinc on ileal smooth muscle. Zinc calcium inraction. lnd.J.Physiol Pharmacol.30:321-328, 1986.

- Daniel EE, Massingham R and Nasmyth PA:The mechanism of conractile effects of ouabain and zinc on the rat uterus. J.Pharmacol.Exp.Ther.173:293-307, 1970.

- Daniel EE, Fair S, Kidwas AM and Polacek I:Zinc and smooth muscle contractility. I.Study of the mechanisms of zinc-induced-contractility changes in rat uteri J Pharmacol. Exp. Ther.178:282-289, 1971.

- Cho CH and Teh GW:The inhibitory action of zinc sulphate on the contractile activity of guinea-pig ileum. 43:294-296, 1991.

- Sarria B, Cartijo J, Marti-Cabrera M, et al:Antagonism of ca 2+ by zinc in guinea-pig isolated taena caeci and trachealis muscle. Br.J.Pharmacol.97:19-26, 1989.

- Cortijo J, Espluques JV, 5arria B, et al:Zinc as a calcium antagonist:A pharmacological approach in the strips of rat aorta. IRCS Med Sci.13:292-293, 1985.

- Nayler WG, and Anderson JE:Effect of zinc on cardiac muscle contraction. Am.J.Physiol.209:17- 21, 1965.

- Sandow A, Taylor 5R, and Preuer H:Role of the action potential in excitation-contraction coupling. Fed.Proc.Fed.Am.Soc.Exp.Biol.24:1116-1123, 1965.

- Taylor SR:ertebrate striated muscle:Length-dependence of Calcium release during contraction. Eur.J.Cardiol.4:31-38, 1976

- Taylo SR, Lopez JR, Girifiths, et al:Calcium in excitation-contraction coupling of frog skeletal muscle.Can.J.Physiol.Phannacol.60:489-502, 1982.

- Gölgeli A, Dursun N, Süer C ve ark:İzole sıçan diyafragma kas kontraksiyonuna çinkonun etkisi. TÜSAD XXII.Ulusal Kongresi, Özet Kitabı TP 92, 18-21 Eylül 1994.

- Standfield PR:The effect of zinc on the gating of the delayed potassium conductance of frog sartorius muscle.J.Physiol(London) 251:711-735, 1975.