INVESTIGATION OF ZINC DEFICIENCY ON CHROMOSOMAL ABNORMALITIES IN MICE

Yusuf ÖZKUL

doi:10.58600/eurjther.1995-6-2-1522-arch

Authors

Yusuf ÖZKUL Erciyes Univ. Tıp Fak. Tıbbi Biyoloji ABD.

DOI:

https://doi.org/10.58600/eurjther.1995-6-2-1522-arch

Keywords:

Zinc Deficiency, Chromosomal Abnormalities

Abstract

The present study investigated the effect of zinc-deficiency on chromosomal abnormalities and mitotic index, and the interaction of zinc deficiency and methotrexate. Therefore, two zinc-deficient and two zinc-adequate diet received mice groups were constituted. Methotrexate was injected to one of zinc-deficient and one of zinc-adequate diet groups. There were no structural and numerical abnonnalities in all groups. However, mitotic index was significantly lower than other groups in zinc-deficient and methotrexate administered mice.

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