Biochemical and Scintigraphic Evaluation of Effect of Extracorporeal Shock Wave Lithotripsy

Abstract

With Multimed 9200 Lithotriptor 23, patients diagnosed kidney stone at Urology Department of Gaziantep University Medical Faculty, between May 1993 to April 1994 was treated. To determine the effect of ESWL to kidney and surroıınding tissues we evaluated GFR, Tmax, Umax, transition of Tc 99ın DTPA through the kidney, excretion time and response to the diuretics before ESWL and after ESWL l.day and 1. month.We evaluated ıırine volume, urine creatinine and creatinine clearence, BUN, SGOT, SGPT, total bilirııbin, total protein, albumin, sodium, potassium, clor and uric asidin blood. On the first after ESWL, there was a decrease in average GFR, lengthened Tc 99m DTPA transition time and Tmax., decreased Umax. volume but all these changes were not found to be statistically significant (P>0.05). All these changes were normal atfirst month. In the other kidney which is not treated there was a statistically signifıcant increase of mean GFR value. Other scintigraphic parameters were normal. At first day after ESWL there were statistically significant decrease at creatinin clearence and urine creatinine and signifıcant increase of urine volume (P<0.05). After ESWL while a statistically signifıcant decrease in serum total protein and uric acid seen, but these were not clinically important and other parameters were unchanged. Recovery of these acute changes at first month of ESWL made us to think these effects were not persistent and scintigraphy is a useful methot for evaluation of after ESWL changes.