Rectum Cancer and Human Papillomavirus Infections

Hamiyet  DÖNMEZ; Adnan MENEVŞE; Seren  ÖZENİRLER

doi:10.58600/eurjther.1998-9-1-2-1436-arch

Authors

Hamiyet DÖNMEZ Erciyes Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı
Adnan MENEVŞE Gazi Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji ve Genetik Anabilim Dalı
Seren ÖZENİRLER Gazi Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı

DOI:

https://doi.org/10.58600/eurjther.1998-9-1-2-1436-arch

Keywords:

Human papillomavirus, rectal adenocarcinoma

Abstract

Human Papillonıavirus (HPV) infections have been implicated in anogenital neoplasia in both sexes. in this study, HPV has been shown to be associated with rectal adenocarcinomas. We used a consensus prinıer polymerase chain reaction DNA amplification methods for the detection and typing of human papillonıavirus in I 4 patients with rectum cancers. The cases were further tested by restriction endonuclease enzynıe analysis for HPV types 6, I I, 16, I 8, 3 I, 39, 51 and 58. By polymerase chain reaction, human papillomavirus 18 DNA was demonstrated in two of I 4 rectum cancer cases. No HPV DNA amplification was detected in the other patients. These data indicate that an association exists between human papillomavirus and rectum cancer. The reason(s) why HPV is associated with adenocarcinoma of the rectum, despite presence of HPV in genital cancers, requires further study.

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